Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators

被引:8
|
作者
Lukitsch, Benjamin [1 ,2 ]
Ecker, Paul [1 ,2 ,3 ]
Elenkov, Martin [2 ,3 ]
Janeczek, Christoph [2 ,3 ]
Jordan, Christian [1 ]
Krenn, Claus G. [2 ,4 ]
Ullrich, Roman [2 ,4 ]
Gfoehler, Margit [3 ]
Harasek, Michael [1 ]
机构
[1] TU Wien, Inst Chem Environm & Biosci Engn, A-1060 Vienna, Austria
[2] CCORE Technol GmbH, A-1040 Vienna, Austria
[3] TU Wien, Inst Engn Design & Prod Dev, A-1060 Vienna, Austria
[4] Med Univ Vienna, Dept Anaesthesia Intens Care Med & Pain Med, A-1090 Vienna, Austria
来源
BIOENGINEERING-BASEL | 2021年 / 8卷 / 03期
关键词
blood oxygenator; carbon dioxide (CO2) removal; carbon dioxide (CO2) solubility model; model performance; model suitability; evaluation; porcine blood; bovine blood;
D O I
10.3390/bioengineering8030033
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
CO2 removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO2 removal rate is necessary. It can either be determined by measuring the CO2 content in the exhaust gas of the oxygenator (sweep flow-based) or using blood gas analyzer data and a CO2 solubility model (blood-based). In this study, we determined the CO2 removal rate of a prototype oxygenator utilizing both methods in in vitro trials with bovine and in vivo trials with porcine blood. While the sweep flow-based method is reliably accurate, the blood-based method depends on the accuracy of the solubility model. In this work, we quantified performances of four different solubility models by calculating the deviation of the CO2 removal rates determined by both methods. Obtained data suggest that the simplest model (Loeppky) performs better than the more complex ones (May, Siggaard-Anderson, and Zierenberg). The models of May, Siggaard-Anderson, and Zierenberg show a significantly better performance for in vitro bovine blood data than for in vivo porcine blood data. Furthermore, the suitability of the Loeppky model parameters for bovine blood (in vitro) and porcine blood (in vivo) is evaluated.
引用
收藏
页码:1 / 25
页数:25
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