Genetic Variation at Chromosome 1p13.3 Affects Sortilin mRNA Expression, Cellular LDL Uptake and Serum LDL Levels Which Translates to the Risk of Coronary Artery Disease

被引：0

作者：

Linsel-Nitschke, Patrick ^{[1
]}

Heeren, Joerg ^{[2
]}

Aherrahrou, Zouhair ^{[1
]}

Gieger, Christian ^{[3
]}

Illig, Thomas ^{[3
]}

Prokisch, Holger ^{[3
]}

Peters, Annette ^{[3
]}

Meitinger, Thomas ^{[3
,4
]}

Wichmann, Erich ^{[5
,6
]}

Hinney, Anke ^{[7
]}

Reinehr, Thomas ^{[8
]}

Roth, Christian ^{[9
]}

Ortlepp, Jan ^{[10
]}

Soufi, Mouhidien ^{[11
]}

Schaefer, Juergen R. ^{[11
]}

Stark, Klaus ^{[12
]}

Hengstenberg, Christian ^{[12
]}

Schaefer, Arne ^{[13
]}

Schreiber, Stefan ^{[13
]}

Kronenberg, Florian ^{[14
]}

Samani, Nilesh J. ^{[15
]}

Schunkert, Heribert ^{[1
]}

Erdmann, Jeanette ^{[1
]}

机构：

[1] Univ Lubeck, Lubeck, Germany

[2] Univ Hamburg, Hamburg, Germany

[3] Helmholtz Cntr Munich, Munich, Germany

[4] Tech Univ Munich, Munich, Germany

[5] Helmholtz Cntr Munich, Lubeck, Germany

[6] Luwig Maximilians Univ, Lubeck, Germany

[7] Univ Duisburg Essen, Essen, Germany

[8] Univ Witten Herdecke, Datteln, Germany

[9] Univ Washington, Seattle, WA 98195 USA

[10] Rhein Westfal TH Aachen, Aachen, Germany

[11] Univ Marburg, Marburg, Germany

[12] Univ Regensburg, Regensburg, Germany

[13] Univ Kiel, Kiel, Germany

[14] Med Univ Innsbruck, Innsbruck, Austria

[15] Univ Leicester, Leicester, Leics, England

来源：

CIRCULATION | 2009年 / 120卷 / 18期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：S563 / S564

页数：2

共 11 条

[1] Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
Linsel-Nitschke, Patrick
Heeren, Joerg
Aherrahrou, Zouhair
Bruse, Petra
Gieger, Christian
Illig, Thomas
Prokisch, Holger
Heim, Katharina
Doering, Angela
Peters, Annette
Meitinger, Thomas
Wichmann, H. -Erich
Hinney, Anke
Reinehr, Thomas
Roth, Christian
Ortlepp, Jan. R.
Soufi, Mouhidien
Sattler, Alexander M.
Schaefer, Juergen
Stark, Klaus
Hengstenberg, Christian
Schaefer, Arne
Schreiber, Stefan
Kronenberg, Florian
Samani, Nilesh J.
Schunkert, Heribert
Erdmann, Jeanette
[J]. ATHEROSCLEROSIS, 2010, 208 (01) : 183 - 189
[2] The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
Rizk, Nasser M.
El-Menyar, Ayman
Egue, Huda
Wais, Idil Souleman
Baluli, Hissa Mohamed
Alali, Khalid
Farag, Fathi
Younes, Noura
Al Suwaidi, Jassim
[J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
[3] The association between serum LDL-cholesterol and genetic variation in chromosomal locus 1p13.3 among coronary artery disease patients in Qatar
Rizk, Nasser M.
El-Menyar, Ayman
Egue, Huda
Wais, Idil
Al Suwaidi, Jassim
[J]. CIRCULATION, 2012, 125 (19) : E916 - E916
[4] Significant impact of genetic variants on chromosomal locus 1p13.3 on serum LDL-cholesterol and on angiographically characterized coronary artery disease
Muendlein, A.
Geller-Rhomberg, S.
Saely, C. H.
Sonderegger, G.
Rein, P.
Beer, S.
Vonbank, A.
Winder, T.
Drexel, H.
[J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2009, 39 : 43 - 43
[5] Genetic variation at chromosome 1p13.3 modulates low density lipoprotein levels and risk of coronary artery disease across multiple populations
Linsel-Nitschke, P.
Goetz, A.
Peters, A.
Prokisch, H.
Meitinger, T.
Wichmann, E.
Ortlepp, J. R.
Kronenberg, F.
Erdmann, J.
Schunkert, H.
[J]. EUROPEAN HEART JOURNAL, 2008, 29 : 790 - 790
[6] Significant Impact of Genetic Variants on Chromosomal Locus 1p13.3 on Serum LDL-Cholesterol and on Angiographically Characterized Coronary Artery Disease
Saely, Christoph H.
Muendlein, Axel
Geller-Rhomberg, Simone
Sonderegger, Gudrun
Rein, Philipp
Beer, Stefan
Vonbank, Alexander
Drexel, Heinz
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (10) : A347 - A347
[7] SIGNIFICANT IMPACT OF GENETIC VARIANTS ON CHROMOSOMAL LOCUS 1P13.3 ON SERUM LDL-CHOLESTEROL AND ON ANGIOGRAPHICALLY CHARACTERIZED CORONARY ARTERY DISEASE
Muendlein, A.
Geller-Rhomberg, S.
Saely, C.
Sonderegger, G.
Rein, P.
Beer, S.
Vonbank, A.
Drexel, H.
[J]. ATHEROSCLEROSIS SUPPLEMENTS, 2009, 10 (02)
[8] A novel locus -: PSRC1/CELSR2 gene locus on chromosome 1p13.3, which affects serum cholesterol and is associated with increased risk of coronary artery disease
Braund, P.
Erdmann, J.
Tomaszewski, M.
Goetz, A.
Hajat, C.
Linsel-Nitschke, P.
Mangino, M.
Hengstenberg, C.
Stevens, S. E.
Stark, K.
Ziegler, A.
Pollard, H.
Caulfield, M.
Hall, A. S.
Burton, P. R.
Schunkert, H.
Tobin, M. D.
Samani, N. J.
[J]. HEART, 2008, 94 : A2 - A3
[9] A recently identified genetic variant for coronary artery disease risk on chromosome 1p13.3 in the region of the PSRC1 and CELSR2 genes associates with serum cholesterol
Braund, P. S.
Erdmann, J.
Tobin, M. D.
Gotz, A.
Tomaszewski, M.
Linsel-Nitschke, P.
Hajat, C.
Hengstenberg, C.
Schunkert, H.
Samani, N. J.
[J]. EUROPEAN HEART JOURNAL, 2008, 29 : 790 - 790
[10] Genetic variation in the oxidized LDL-receptor-1 (OLR1)gene and the risk of coronary artery disease.
Chen, Q
Reis, SE
Kammerer, C
Luedecking-Zimmer, E
McNamara, DM
Pauly, DF
Sharai, B
Holubkov, R
Merz, NB
Sopko, G
Kamboh, MI
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) : 348 - 348

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