Endotheliitis, endothelin, and endothelin receptor blockers in COVID-19

被引：11
|
作者：
Sanghavi, Devang K. [1 ]
Titus, Anoop [3 ]
Caulfield, Thomas R. [2 ]
Freeman, W. David [2 ]
机构：
[1] Mayo Clin, Dept Crit Care Med, Jacksonville, FL 32224 USA
[2] Mayo Clin, Dept Neurol Surg, Jacksonville, FL 32224 USA
[3] St Vincent Hosp, Dept Internal Med, Worcester, MA 01604 USA
来源：
MEDICAL HYPOTHESES | 2021年 / 150卷
关键词：
Bosentan; COVID-19; Endothelin; Endothelin receptor blockers; Endotheliitis; Sitaxentan;
D O I：
10.1016/j.mehy.2021.110564
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We summarize the role of endothelin as a potent vasoconstrictor, pro-inflammatory, pro-oxidative agent in the pathophysiologic effects and end-organ dysfunction of coronavirus disease 2019 (COVID-19). Endotheliitis is an under-recognized pathophysiologic process that causes various types of dysfunction in end organs, including heart, lung, kidney, and brain. Endothelin receptor blockers, such as bosentan and sitaxentan, can pave a path ahead in the realm of COVID-19 therapies. These agents have a potential role against COVID-19 and should be studied in research trials to determine their efficacy in treatment of this severe disease.
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页数：3
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