Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation

被引：50

作者：

Xu, Feng ^{[2
]}

Moon, Sangjun ^{[2
]}

Zhang, Xiaohui ^{[2
]}

Shao, Lei ^{[2
]}

Song, Young Seok ^{[1
]}

Demirci, Utkan ^{[2
,3
]}

机构：

[1] Dankook Univ, Polymer Syst Div, Yongin, Gyeonggi Do, South Korea

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Bioengn,Bioacoust MEMS Med BAMM Lab,Dept Med, Boston, MA 02115 USA

[3] Harvard Massachusetts Inst Technol Hlth Sci & Tec, Cambridge, MA USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2010年 / 368卷 / 1912期

关键词：

multi-scale modelling; heat and mass transfer; cryopreservation; THERMAL-STRESSES; NUMERICAL-SIMULATION; KEDEM-KATCHALSKY; ENERGY EQUATION; BOVINE OOCYTES; COOLING RATES; COLD SHOCK; 2ND SOUND; VITRIFICATION; CONDUCTION;

D O I：

10.1098/rsta.2009.0248

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cells and tissues undergo complex physical processes during cryopreservation. Understanding the underlying physical phenomena is critical to improve current cryopreservation methods and to develop new techniques. Here, we describe multi-scale approaches for modelling cell and tissue cryopreservation including heat transfer at macroscale level, crystallization, cell volume change and mass transport across cell membranes at microscale level. These multi-scale approaches allow us to study cell and tissue cryopreservation.

引用

页码：561 / 583

页数：23

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