Aerobic Copper-Catalyzed Synthesis of (E)-Vinyl Sulfones by Direct C-S Bond Oxidative Coupling

被引：32
|
作者：
Liang, Xiao [1 ]
Xiong, Mingteng [1 ]
Zhu, Heping [1 ]
Shen, Kexin [2 ]
Pan, Yuanjiang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310027, Zhejiang, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 17期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
SULFINIC ACID SALTS; VINYL SULFONES; STEREOSELECTIVE-SYNTHESIS; SELECTIVE SYNTHESIS; METAL-FREE; ATOM ECONOMY; ARYL HALIDES; SULFONYLATION; SULFOXIDES; EFFICIENT;
D O I：
10.1021/acs.joc.9b01400
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed aerobic oxidative C-S bond coupling reaction between thiophenols and aryl-substituted alkenes for (E)-vinyl sulfones synthesis is reported here. With air utilized as a green oxidant, this transformation not only produces various vinyl sulfones in moderate to good yields but also possesses a simple and ecofriendly system. To clarify the mechanism, kinetic experiments has been investigated.
引用
收藏
页码：11210 / 11218
页数：9
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