Association of CACNA1C polymorphisms with serum BDNF levels in bipolar disorder

被引：10
|
作者：
Smedler, Erik [1 ]
Palsson, Erik [1 ]
Hashimoto, Kenji [2 ]
Landen, Mikael [1 ,3 ]
机构：
[1] Gothenburg Univ, Sahlgrenska Acad, Sect Psychiat & Neurochem, Gothenburg, Sweden
[2] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba, Japan
[3] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
来源：
BRITISH JOURNAL OF PSYCHIATRY | 2021年 / 218卷 / 02期
基金：
瑞典研究理事会;
关键词：
Bipolar disorder; endophenotypes; biomarkers; CACNA1C; brain-derived neurotrophic factor;
D O I：
10.1192/bjp.2019.173
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Variation in the CACNA1C gene has been associated with bipolar disorder in several genome-wide association studies. This gene encodes the alpha 1C subunit of L-type voltage-gated calcium channels, which play an essential role in neurons. We analysed 39 biomarkers in either cerebrospinal fluid or serum in relation to six different CACNA1C variants in 282 patients with bipolar disorder and 90 controls. We report associations of CACNA1C risk alleles with serum levels of BDNF as well as tissue plasminogen activator, which converts pro-BDNF to mature BDNF. This sheds light on links between CACNA1C genetic variants and pathophysiological mechanisms in bipolar disorder.
引用
收藏
页码：77 / 79
页数：3
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