Genetic variation of FUT2 in a Ghanaian population:: identification of four novel mutations and inference of balancing selection

被引：23
|
作者：
Soejima, Mikiko [1 ]
Pang, Hao [1 ]
Koda, Yoshiro [1 ]
机构：
[1] Kurume Univ, Sch Med, Dept Forens Med & Human Genet, Kurume, Fukuoka 8300011, Japan
来源：
ANNALS OF HEMATOLOGY | 2007年 / 86卷 / 03期
关键词：
balancing selection; DHPLC; FUT2; secretor;
D O I：
10.1007/s00277-006-0203-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The FUT2 is rich in polymorphisms that show population-specific patterns in its coding sequence. In this study, we found four novel substitutions in 121 Ghanaian samples. In addition, statistical tests considering population expansion scenarios suggested that balancing selection might be responsible for the genetic diversity of FUT2 in this population.
引用
收藏
页码：199 / 204
页数：6
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