Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists

被引：14
|
作者：
Chu, Guo-Hua [1 ]
Saeui, Christopher T. [1 ]
Worm, Karin [1 ]
Weaver, Damian G. [1 ]
Goodman, Allan J. [1 ]
Broadrup, Robert L. [1 ]
Cassel, Joel A. [2 ]
DeHaven, Robert N. [2 ]
LaBuda, Christopher J. [2 ]
Koblish, Michael [2 ]
Brogdon, Bernice [3 ]
Smith, Steve [3 ]
Le Bourdonnec, Bertrand [1 ]
Dolle, Roland E. [1 ]
机构：
[1] Adolor Corp, Dept Chem, Exton, PA 19341 USA
[2] Adolor Corp, Dept Pharmacol, Exton, PA 19341 USA
[3] Adolor Corp, Dept DMPK, Exton, PA 19341 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 20期
关键词：
Cannabinoid receptors; Selective CB2 agonists; Pain; Pyridine derivatives; PAIN; BINDING; ACTIVATION; DISCOVERY; RAT;
D O I：
10.1016/j.bmcl.2009.08.063
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Replacement of the phenyl ring in our previous ( morpholinomethyl) aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of a novel chemical series of CB2 ligands. Compound 3, that is, 2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)butanamide was identified as a potent and selective CB2 agonist exhibiting in vivo efficacy after oral administration in a rat model of neuropathic pain. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5931 / 5935
页数：5
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