Photoresponsive smart hydrogel microsphere via host-guest interaction for 3D cell culture

被引：14
|
作者：
Ma, Dandan [1 ,2 ,3 ]
Zhou, Naizhen [1 ,2 ,3 ]
Zhang, Tianzhu [1 ,2 ,3 ,4 ]
Hu, Ke [1 ,2 ,3 ]
Ma, Xiao'e [1 ,2 ,3 ]
Gu, Ning [1 ,2 ,3 ,4 ]
机构：
[1] Southeast Univ, State Key Lab Bioelect, Sipailou 2, Nanjing 210096, Jiangsu, Peoples R China
[2] Southeast Univ, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Sipailou 2, Nanjing 210096, Jiangsu, Peoples R China
[3] Southeast Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Sipailou 2, Nanjing 210096, Jiangsu, Peoples R China
[4] Southeast Univ Suzhou, Res Inst, Suzhou Key Lab Biomed Mat & Technol, Ren Ai Rd 150,Suzhou Ind Pk, Suzhou 215123, Peoples R China
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2017年 / 522卷
基金：
中国国家自然科学基金;
关键词：
Photoresponsive; Hydrogel; 3D cell culture; beta-Cyclodextrin; Azobenzene; FABRICATION; SURFACES; ADHESION; DENSITY; DESIGN;
D O I：
10.1016/j.colsurfa.2017.02.073
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this study, we designed a kind of photoresponsive hydrogel microsphere for three-dimensional (3D) cell culture, which is based on the host-guest interaction of beta-cyclodextrin (beta-CD) and Azobenzene. The hydrogel microsphere consists of polyethylene glycol (PEG) and beta-CD modified poly(methyl vinyl ether-alt-maleic acid) (PMVE-alt-MA) which was allowed to assemble with azobenzene-arginine-glycine-aspartate (Azo-RGD) via host-guest interaction for controlling cell adhesion and detachment. UV irradiation led to the detachment of Azo-RGD from hydrogel microsphere, and the number of cells cultured on the hydrogel microsphere surface was reduced subsequently. This photo-switchable surface can achieve the controllability of cells adhesion and detachment. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：97 / 104
页数：8
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