Synthesis and Characterization of Floxuridine-Layered Double Hydroxide Nanohybrids

The intercalation of Floxundine into layered double hydroxide(LDHs) was used via coprecipitation method to obtain Floxuridine-LDHs nanohybrids. According to the gallery height of Floxuridine-LDHs and size of floxuridine molecule, a possible morphology of floxuridine molecules in the gallery of LDHs is suggested that floxuridine molecules are intercalated into the gallery of LDHs with a vertical-arranged bilayer along the long axis. The release kinetics of floxuridine from the nanohybrids was investigated at pH value of 4.8 and 7.2, respectively. It is found that the nanohybrids can control the release of floxuridine, and the in vitro drug release from the nanohybrids is remarkably lower than that from the corresponding physical mixture. The release rate of floxuridine decreases with the increase of floxuridine loading and the whole release process may fit to the pseudo-second-order release kinetics.