Genetic and epigenetic changes of the FHIT gene in patients with esophageal cancer

被引：0
|
作者：
Tsao, Yu [1 ]
Atramentova, L. A. [1 ]
机构：
[1] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine
来源：
CYTOLOGY AND GENETICS | 2009年 / 43卷 / 06期
关键词：
SQUAMOUS-CELL CARCINOMA; HYPERMETHYLATION; EXPRESSION; INACTIVATION; METHYLATION;
D O I：
10.3103/S009545270906005X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Deletions in the fifth and eighth exons of FHIT gene were detected using intragenic microsatellites D3s1540 and D3s1234 in 17 males and 5 females with esophageal cancer. The patients were residents of Hebei province, China. Homozygotic deletions in the fifth and eighth exons were detected in 16 of 22 patients. Hypermethylation of the FHIT gene was found in the healthy tissue of only one patient and in the cancerous tissue of 17 patients. Homozygosity of the FHIT gene due to deletion or hypermethylation was found in the cancer tissues of all the patients.
引用
收藏
页码：396 / 400
页数：5
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