Association of 17 Prostate Cancer Susceptibility Loci With Prostate Cancer Risk in Chinese Men

BACKGROUND. Several genome-wide association studies (GWAS) in populations of European descent have identified more than a dozen common genetic variants that are associated with prostate cancer risk. METHODS. To determine whether these variants are also associated with prostate cancer risk in the Chinese population, we evaluated 17 prostate cancer susceptibility loci in a population-based case-control study from Shanghai, including 288 prostate cancer cases and 155 population controls. RESULTS. After adjustment for age, two of the 17 loci were significantly associated with prostate cancer risk, while the other 15 loci were suggestively associated with prostate cancer risk in this population. The strongest associations were found for chromosome 8q24 Region 2 (rsl016343: OR=2.07, 95% CI: 1.35-3.20, P=9.4 x 10(-4)) and 8q24 Region 1 (rs10090154: OR = 2.07, 95% CI: 1.31-3.28, P = 0.002); additional single nucleotide polymorphisms (SNPs) assessed in these two 8q24 regions were also significant (ORRegion2 = 1.92-2.05, P = 9.4 x 10(-4) to 0.003, and ORRegion1 = 1.77-1.81, P = 0.01 for all SNPs). CONCLUSIONS. Our study shows that multiple prostate cancer risk loci identified in European populations by GWAS are also associated with prostate cancer risk in Chinese men, a low-risk population with mostly clinically relevant cancers. Larger studies in Chinese and Asian populations are needed to confirm these findings and the role of these risk loci in prostate cancer etiology in Asian men. Prostate 70: 425-432, 2010. (C) 2009 Wiley-Liss, Inc.