An Improved Procedure for the Preparation of [Bis(2,2,2-trifluoroethyl)phosphono]acetic Acid

被引：3
|
作者：
Prado, Viviana da Silva [1 ]
Burtoloso, Antonio Carlos B. [1 ]
机构：
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
来源：
SYNTHESIS-STUTTGART | 2010年 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
bis(2,2,2-trifluoroethyl)phosphono]acetic acid; Horner-Wadsworth-Emmons (HWE) reaction; Michaelis-Becker reaction; Still-Gennari reagents; WADSWORTH-EMMONS REACTION; LEUCASCANDROLIDE-A; PHORBOXAZOLE; OLEFINATION; CARBANIONS; ESTERS; ANALOG;
D O I：
10.1055/s-0029-1217086
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A different and improved procedure for the preparation of [bis(2,2,2-trifluoroethyl)phosphono]acetic acid in just one step from bis(2,2,2-trifluoroethyl)phosphonate is described. The protocol employs a Michaelis-Becker reaction between commercially available bis(2,2,2-trifluoroethyl) phosphonate and bromoacetic acid, furnishing [bis(2,2,2-trifluoroethyl)phosphono]acetic acid in 50-54% yield.
引用
收藏
页码：361 / 363
页数：3
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