Isolation of two distinct prion strains from a scrapie-affected sheep

被引：9

作者：

Masujin, Kentaro ^{[1
]}

Shu, Yujing ^{[1
]}

Okada, Hiroyuki ^{[1
]}

Matsuura, Yuichi ^{[1
]}

Iwamaru, Yoshifumi ^{[1
]}

Imamura, Morikazu ^{[1
]}

Mohri, Shirou ^{[1
]}

Yokoyama, Takashi ^{[1
]}

机构：

[1] Natl Inst Anim Hlth, Prion Dis Res Ctr, Tsukuba, Ibaraki 3050856, Japan

来源：

ARCHIVES OF VIROLOGY | 2009年 / 154卷 / 12期

关键词：

SPONGIFORM ENCEPHALOPATHY BSE; BIOCHEMICAL-CHARACTERIZATION; PROTEIN; AGENT; ANTIBODIES; ISOFORMS; HAMSTERS; DISEASE; JAPAN; BRAIN;

D O I：

10.1007/s00705-009-0534-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We performed a transmission study using mice to clarify the characteristics of the most recent case of scrapie in Japan. The mice that were inoculated with the brain homogenate from a scrapie-affected sheep developed progressive neurological disease, and one of the scrapie-affected mice showed unique clinical signs during primary transmission. This mouse developed obesity, polydipsia, and polyuria. In contrast, the other affected mice exhibited weight loss and hypokinesia. In subsequent passages, the mice showed distinct characteristic scrapie phenotypes. This finding may prove that different prion strains coexist in a naturally affected sheep with scrapie.

引用

页码：1929 / 1932

页数：4

共 50 条

[1] Isolation of two distinct prion strains from a scrapie-affected sheep
Kentaro Masujin
Yujing Shu
Hiroyuki Okada
Yuichi Matsuura
Yoshifumi Iwamaru
Morikazu Imamura
Shirou Mohri
Takashi Yokoyama
[J]. Archives of Virology, 2009, 154 : 1929 - 1932
[2] Prion protein gene polymorphisms in healthy and scrapie-affected sheep in Greece
Billinis, C
Psychas, V
Leontides, L
Spyrou, V
Argyroudis, S
Vlemmas, I
Leontides, S
Sklaviadis, T
Papadopoulos, O
[J]. JOURNAL OF GENERAL VIROLOGY, 2004, 85 : 547 - 554
[3] Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep
Picard-Hagen, Nicole
Gayrard, Veronique
Viguie, Catherine
Moudjou, Mohammed
Imbs, Chantal
Toutain, Pierre-Louis
[J]. JOURNAL OF GENERAL VIROLOGY, 2006, 87 : 3723 - 3727
[4] Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep
Acín, C
Martín-Burriel, I
Goldmann, W
Lyahyai, J
Monzón, M
Bolea, R
Smith, A
Rodellar, C
Badiola, JJ
Zaragoza, P
[J]. JOURNAL OF GENERAL VIROLOGY, 2004, 85 : 2103 - 2110
[5] CEREBROVASCULAR AMYLOID IN SCRAPIE-AFFECTED SHEEP REACTS WITH ANTIBODIES TO PRION PROTEIN
ALLSOP, D
IKEDA, S
BRUCE, M
GLENNER, GG
[J]. NEUROSCIENCE LETTERS, 1988, 92 (02) : 234 - 239
[6] CEREBROVASCULAR AMYLOIDOSIS IN SCRAPIE-AFFECTED SHEEP
GILMOUR, JS
BRUCE, ME
MACKELLAR, A
[J]. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1986, 12 (02) : 173 - 183
[7] Intraepithelial and Interstitial Deposition of Pathological Prion Protein in Kidneys of Scrapie-Affected Sheep
Ligios, Ciriaco
Cancedda, Giovanna Maria
Margalith, Ilan
Santucciu, Cinzia
Madau, Laura
Maestrale, Caterina
Basagni, Massimo
Saba, Mariangela
Heikenwalder, Mathias
[J]. PLOS ONE, 2007, 2 (09):
[8] A behavioural study of scrapie-affected sheep
Healy, AM
Hanlon, AJ
Weavers, E
Collins, JD
Doherty, ML
[J]. APPLIED ANIMAL BEHAVIOUR SCIENCE, 2002, 79 (02) : 89 - 102
[9] Prion protein gene polymorphisms in classical scrapie-affected flocks of sheep in Central Macedonia
Kioutsioukis, C.
Papadogiannakis, E.
Palaska, V
Kontos, V
Papakostaki, D.
Paraskeva, S.
Vassalou, E.
[J]. JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY, 2018, 69 (02): : 931 - 940
[10] SPREAD OF SCRAPIE TO SHEEP AND GOATS BY ORAL DOSING WITH FETAL MEMBRANES FROM SCRAPIE-AFFECTED SHEEP
PATTISON, IH
WATSON, WA
HOARE, MN
JEBBETT, JN
[J]. VETERINARY RECORD, 1972, 90 (17) : 465 - +

← 1 2 3 4 5 →