Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-α in the context of inflammation

被引：14

作者：

Prathap, Lavanya ^{[1
]}

Jayaraman, Selvaraj ^{[2
]}

Roy, Anitha ^{[3
]}

Santhakumar, Preetha ^{[4
]}

Jeevitha, M. ^{[5
]}

机构：

[1] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Anat, Chennai 600077, Tamil Nadu, India

[2] Saveetha Inst Med & Tech Sci, Dept Biochem, Saveetha Dent Coll & Hosp, Chennai 600077, Tamil Nadu, India

[3] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Pharmacol, Chennai 600077, Tamil Nadu, India

[4] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Physiol, Chennai 600077, Tamil Nadu, India

[5] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Periodont, Chennai 600077, Tamil Nadu, India

来源：

BIOINFORMATION | 2021年 / 17卷 / 02期

关键词：

IL-6; TNF-alpha; inflammation; molecular docking; DISEASE;

D O I：

10.6026/97320630017363

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammatory is cascade process triggered by pro-inflammatory cytokines and anti-inflammatory. In the present study anti-inflammatory activity of Stachydrine and Sakuranetin were studied against the inflammatory target proteins IL-6 and TNF-alpha by using molecular docking analysis. Both compounds showed the good binding with selected target proteins. Compared to Sakuranetin, the Stachydrine have lowest binding energy and good hydrogen bond interactions. Hence results of study indicated that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-a and interleukin-6.

引用

页码：363 / 368

页数：6

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