Autologous bone-marrow stem-cell transplantation for myocardial regeneration

被引：1077
|
作者：
Stamm, C
Westphal, B
Kleine, HD
Petzsch, M
Kittner, C
Klinge, H
Schümichen, C
Nienaber, CA
Freund, M
Steinhoff, G [1 ]
机构：
[1] Univ Rostock, Dept Cardiac Surg, D-18057 Rostock, Germany
[2] Univ Rostock, Dept Haematol & Oncol, D-18057 Rostock, Germany
[3] Univ Rostock, Dept Cardiol, D-18057 Rostock, Germany
[4] Univ Rostock, Dept Radiol, D-18057 Rostock, Germany
来源：
LANCET | 2003年 / 361卷 / 9351期
关键词：
D O I：
10.1016/S0140-6736(03)12110-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5x10(8) autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3-9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the Infarcted myocardium..
引用
收藏
页码：45 / 46
页数：2
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