Self-reported sleep disturbance and survival in myelodysplastic syndromes

被引:17
|
作者
Luskin, Marlise R. [1 ,2 ]
Cronin, Angel M. [1 ]
Owens, Robert L. [3 ]
DeAngelo, Daniel J. [1 ,2 ]
Stone, Richard M. [1 ,2 ]
Wadleigh, Martha [1 ,2 ]
Steensma, David P. [1 ,2 ]
Abel, Gregory A. [1 ,2 ]
机构
[1] Dana Farber Canc Inst, 450 Brookline Ave,Dana 2056, Boston, MA 02215 USA
[2] Harvard Med Sch, Boston, MA USA
[3] Univ Calif San Diego, San Diego, CA 92103 USA
关键词
myelodysplastic syndromes; sleep; fatigue; quality of life; overall survival; QUALITY-OF-LIFE; INSOMNIA SYMPTOMS; SCORING SYSTEM; CANCER; FATIGUE; TRANSFUSION; PREVALENCE; MORTALITY; ONCOLOGY; MEN;
D O I
10.1111/bjh.14573
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neither the prevalence of sleep disturbance nor its association with fatigue and overall survival (OS) are well understood for patients with myelodysplastic syndromes (MDS). New patients at our institution (n=251; 2006-2014) completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, which includes questions about sleep and fatigue. Fifty-three per cent reported at least a little' trouble sleeping. In multivariable models, anaemia and sleep disturbance were associated with fatigue (both P < 0.001). Additionally, in separate models, sleep disturbance (P = 0.002) and fatigue (P = 0.04) both predicted OS. Our data suggest that improving sleep quality may impact MDS-related fatigue and OS.
引用
收藏
页码:562 / 566
页数:5
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