Gold nanoparticles for 99mTc-doxorubicin delivery: formulation, in vitro characterization, comparative studies in vivo stability and biodistribution

被引：9
|
作者：
El-Safoury, D. M. [1 ]
Ibrahim, Ahmed B. [1 ,2 ]
El-Setouhy, D. A. [3 ]
Khowessah, O. M. [3 ]
Motaleb, M. A. [1 ]
Sakr, Tamer M. [2 ,4 ]
机构：
[1] Egyptian Atom Energy Author, Labeled Cpds Dept, Hot Labs Ctr, Cairo 13759, Egypt
[2] Egyptian Atom Energy Author, Radioisotopes Prod Facil, Egyptian Res Reactor Complex 2, Cairo 13759, Egypt
[3] Cairo Univ, Fac Pharm, Pharmaceut & Ind Pharm Dept, Cairo 11562, Egypt
[4] Egyptian Atom Energy Author, Radioact Isotopes & Generator Dept, Hot Labs Ctr, Cairo 13759, Egypt
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2021年 / 328卷 / 01期
关键词：
Gold nanoparticles; Tc-99m]Tc-Doxorubicin; Direct formulation method; Intra-tumoral (IT); In vivo stability and tumor imaging; DRUG-DELIVERY; PRECLINICAL EVALUATION; BIOLOGICAL EVALUATION; IMAGING PROBE; IRON-OXIDE; DOXORUBICIN; BRAIN; THERAPY; NANOMEDICINE; INTRANASAL;
D O I：
10.1007/s10967-021-07633-y
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The [Tc-99m]Tc-Doxorubicin-Gold Nanoparticles (Tc-99m-Dox-AuNPs) was formulated as a nanoradiopharmaceutical by different loading procedures to enhance tumor targeting. The formula F1 that was prepared by direct loading of pre-prepared [Tc-99m]Tc-Doxorubicin showed a reasonable in-vitro characterization values, high entrapment efficiency (92 +/- 0.72%), acceptable in vitro release data and convenient in-vitro serum stability up to 24 h. F1 presented high tumor uptake (54%ID/g) with high Target/ Non Target (T/NT) ( approximate to 77) and Drug Target Efficiency percent (%DTE) above 100% at 0.5 h via intra-tumoral injection that prove the increasing of tumor targeting and in-vivo stability by direct loading for pre-prepared [Tc-99m]Tc-Doxorubicin. [GRAPHICS] .
引用
收藏
页码：325 / 338
页数：14
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