Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency virus type 1 infection

被引：48
|
作者：
Yamada, T [1 ]
Iwamoto, A [1 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Dept Infect Dis, Minato Ku, Tokyo 1088639, Japan
来源：
ARCHIVES OF VIROLOGY | 2000年 / 145卷 / 05期
关键词：
D O I：
10.1007/s007050050692
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared proviral accessory gene sequences (nef; vpu, vpr; vif; rev tat) of human immunodeficiency virus type 1 (HIV-1) in the peripheral blood mononuclear cells (PBMC) between seven long-term non-progressors (LTNP) and seven progressors. LTNP frequently harbored proviruses with mutated accessory genes, while almost all accessory genes were intact in progressors. Presence of quasispecies in attenuated viruses suggests that they were not just a fossil record of nonreplication proviruses. These attenuated viruses in LTNP may be the source of their strong immune response against HIV-1. Our result might have relevance to a design of potent therapeutic vaccines.
引用
收藏
页码：1021 / 1027
页数：7
相关论文
共 50 条
  • [1] Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency virus type 1 infection
    T. Yamada
    A. Iwamoto
    [J]. Archives of Virology, 2000, 145 : 1021 - 1027
  • [2] Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors
    Montefiori, DC
    Pantaleo, G
    Fink, LM
    Zhou, JT
    Zhou, JY
    Bilska, M
    Miralles, GD
    Fauci, AS
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (01): : 60 - 67
  • [3] Neutralization escape in human immunodeficiency virus type 1-infected long-term nonprogressors
    Bradney, AP
    Scheer, S
    Crawford, JM
    Buchbinder, SP
    Montefiori, DC
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (05): : 1264 - 1267
  • [4] Longitudinal quantification of human immunodeficiency virus type 1 DNA and RNA in long-term nonprogressors
    Broström, C
    Visco-Comandini, U
    Yun, ZB
    Sönnerborg, A
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (06): : 1542 - 1548
  • [5] Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors
    Rusconi, S
    Berlusconi, A
    Papagno, L
    Colombo, MC
    deMaddalena, C
    Riva, A
    Bagnarelli, P
    Balotta, C
    Galli, M
    [J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1997, 85 (03): : 320 - 323
  • [6] DEFECTIVE ACCESSORY GENES IN A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED LONG-TERM SURVIVOR LACKING RECOVERABLE VIRUS
    MICHAEL, NL
    CHANG, G
    DARCY, LA
    EHRENBERG, PK
    MARIANI, R
    BUSCH, MP
    BIRX, DL
    SCHWARTZ, DH
    [J]. JOURNAL OF VIROLOGY, 1995, 69 (07) : 4228 - 4236
  • [7] Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection
    Carl, S
    Daniels, R
    Iafrate, AJ
    Easterbrook, P
    Greenough, TC
    Skowronski, J
    Kirchhoff, F
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01): : 132 - 140
  • [8] Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort
    Greenough, TC
    Brettler, DB
    Kirchhoff, F
    Alexander, L
    Desrosiers, RC
    O'Brien, SJ
    Somasundaran, M
    Luzuriaga, K
    Sullivan, JL
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06): : 1790 - 1802
  • [9] LONG-TERM SURVIVORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - REPLY
    HO, DD
    CAO, YZ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (24): : 1647 - 1648
  • [10] Long terminal repeat and nef gene variants of human immunodeficiency virus type 1 in perinatally infected long-term survivors and rapid progressors
    Rousseau, C
    Abrams, E
    Lee, M
    Urbano, R
    King, MC
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1997, 13 (18) : 1611 - 1623
12345