Inhibition of HMG-COA reductase activity with statins provides acute-g raft-versus-host disease protection by TH-2 cytokine induction while sparing graft-versus-leukemia activity

被引：0
|
作者：
Zeiser, R.
Yotissef, S.
Baker, I.
Steinman, L.
Negrin, R.
机构：
[1] Stanford Univ, Dept Med, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Neurol, Stanford, CA 94305 USA
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2007年 / 13卷 / 02期
关键词：
D O I：
10.1016/j.bbmt.2006.12.340
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
335
引用
收藏
页码：121 / 122
页数：2
相关论文
共 10 条
  • [1] Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity
    Zeiser, Robert
    Youssef, Sawsan
    Baker, Jeanette
    Kambham, Neeraja
    Steinman, Lawrence
    Negrin, Robert S.
    BLOOD, 2007, 110 (13) : 4588 - 4598
  • [2] Type IIHMG-CoA reductase inhibitors (Statins) provide acute-graft-versus-host disease protection by Th-2 cytokine induction while sparing graft-versus-leukemia activity.
    Zeiser, Robert
    Youssef, Sawsan
    Baker, Jeanette
    Steinman, Lawrence
    Negrin, Robert
    BLOOD, 2006, 108 (11) : 60A - 60A
  • [3] The impact of HMG-CoA reductase inhibition on the incidence and severity of graft-versus-host disease in patients with acute leukemia undergoing allogeneic transplantation
    Hamadani, Mehdi
    Awan, Farrukh T.
    Devine, Steven M.
    BLOOD, 2008, 111 (07) : 3901 - 3902
  • [4] Macrophage Inflammatory Protein-2/CXCR2 Blockade Attenuates Acute Graft-versus-Host Disease while Preserving Graft-versus-Leukemia Activity
    Park, Minhwa
    Cho, Kyung-Ah
    Woo, So-Youn
    Ryu, Kyung-Ha
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [5] Tolerogenic anti-IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity
    Song, Qingxiao
    Wang, Xiaoning
    Wu, Xiwei
    Qin, Hanjun
    Li, Yingfei
    Riggs, Arthur D.
    Martin, Paul J.
    Chen, Yuan-Zhong
    Zeng, Defu
    BLOOD, 2021, 137 (16) : 2243 - 2255
  • [6] Icariin protects against acute graft-versus-host disease while preserving graft-versus-leukemia activity after allogeneic hematopoietic stem cell transplantation
    Su, Long
    Wei, Zhi-Feng
    Pi, Chen-Chen
    Qin, Tian-Xue
    Song, Fei
    Zhang, Yun-Wei
    Gao, Su-Jun
    PHYTOMEDICINE, 2024, 132
  • [7] Macrophage inflammatory protein-2 (MIP-2)/CXCR2 blockade attenuates acute graft-versus-host disease while preserving graft-versus-leukemia activity
    Cho, Kyung-Ah
    Woo, So-Youn
    Park, Yoon Shin
    Park, Min Hwa
    Ryu, Kyung-Ha
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 426 (04) : 558 - 564
  • [8] INTERLEUKIN-2 INHIBITS GRAFT-VERSUS-HOST DISEASE-PROMOTING ACTIVITY OF CD4+ CELLS WHILE PRESERVING CD4-MEDIATED AND CDS-MEDIATED GRAFT-VERSUS-LEUKEMIA EFFECTS
    SYKES, M
    HARTY, MW
    SZOT, GL
    PEARSON, DA
    BLOOD, 1994, 83 (09) : 2560 - 2569
  • [9] Induction of a T helper 2 (Th2) response in CD4+ donor cells leads to enhanced graft-versus-leukemia (GvL) activity and inhibits graft-versus-host disease (GvHD) after allogeneic stem cell transplantation.
    Uharek, L
    Zeis, M
    Hartung, G
    Glass, B
    Dreger, P
    Steinmann, J
    Schmitz, N
    BLOOD, 1997, 90 (10) : 902 - 902
  • [10] Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease?
    Williamson, E
    Garside, P
    Bradley, JA
    More, IAR
    Mowat, AM
    JOURNAL OF IMMUNOLOGY, 1997, 159 (03): : 1208 - 1215
1