TISSUE-SPECIFIC IMMUNE RESPONSES Tissue-mediated control of immunopathology in coeliac disease

被引：223

作者：

Jabri, Bana ^{[1
,2
]}

Sollid, Ludvig M. ^{[3
,4
]}

机构：

[1] Univ Chicago, Dept Med, Dept Pathol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[3] Univ Oslo, Ctr Immune Regulat, Inst Immunol, N-0027 Oslo, Norway

[4] Oslo Univ Hosp, Rikshosp, N-0027 Oslo, Norway

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSE; INTESTINAL EPITHELIAL-CELLS; CHRONIC HEPATITIS-C; DENDRITIC CELLS; INTRAEPITHELIAL LYMPHOCYTES; DIABETES-MELLITUS; GLIADIN PEPTIDES; INTERFERON-ALPHA; STRUCTURAL BASIS; NATURAL-KILLER;

D O I：

10.1038/nri2670

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation-induced either by infectious agents or by gluten-is crucial for activating T cells and eliciting their tissue-destructive effector functions.

引用

页码：858 / 870

页数：13

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