Dynamic Change of Thyroid Hormones With Postmenstrual Age in Very Preterm Infants Born With Gestational Age <32 Weeks: A Multicenter Prospective Cohort Study

被引：6
|
作者：
Shi, Ranran [1 ,2 ]
Zhang, Ming [1 ,2 ]
Chen, Yao [1 ,2 ]
Han, Meiying [3 ]
Xu, Ping [3 ]
Li, Min [4 ]
Ding, Yanjie [5 ]
Zhang, Xiaohui [5 ]
Kou, Yan [6 ]
Xu, Haiyan [6 ]
Zong, Fangru [7 ]
Liu, Xinjian [8 ]
Wang, Hui [8 ]
He, Haiying [9 ]
Liu, Qiang [10 ]
Kong, Weikang [10 ]
Niu, Shiping [11 ]
Li, Xia [12 ]
Huang, Lei [13 ]
Lu, Qinghua [13 ]
Wang, Xiaofang [14 ]
Deng, Liping [14 ]
Yang, Zhenying [15 ]
Zhang, Xiao [15 ]
Sun, Rongrong [16 ]
Zhao, Riming [17 ]
Shi, Jing [18 ]
Peng, Fudong [18 ]
Sun, Xueming [19 ]
Zhao, Guoying [20 ]
Zhao, Xinfeng [21 ]
Ge, Yonghong [22 ]
Zhang, Nan [23 ]
Zhu, Renxia [24 ]
Li, Jing [25 ]
Li, Haiyan [26 ]
Hao, Huijuan [27 ]
Yu, Yonghui [1 ,2 ]
机构：
[1] Shandong First Med Univ, Shandong Prov Hosp, Dept Neonatol, Jinan, Peoples R China
[2] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Neonatol, Jinan, Peoples R China
[3] Liaocheng Peoples Hosp, Dept Neonatol, Liaocheng, Shandong, Peoples R China
[4] Linyi Maternal & Child Hlth Hosp, Dept Neonatol, Linyi, Shandong, Peoples R China
[5] Yantai Yuhuangding Hosp, Dept Neonatol, Yantai, Peoples R China
[6] Shandong First Med Univ, Shandong Prov Qianfoshan Hosp, Dept Neonatol, Jinan, Peoples R China
[7] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Neonatol, Jinan, Peoples R China
[8] Hebei PetroChina Cent Hosp, Dept Neonatol, Langfang, Peoples R China
[9] Hongci Grp, Dept Neonatol, Baogang Hosp 3, Baotou, Peoples R China
[10] Linyi People S Hosp, Dept Neonatol, Linyi, Shandong, Peoples R China
[11] Zibo Maternal & Child Care Hosp, Dept Neonatol, Zibo, Peoples R China
[12] Jinan Matern & Child Care Hosp, Dept Neonatal Intens Care Unit, Jinan, Peoples R China
[13] Shandong Maternal & Child Hlth Hosp, Dept Neonatol, Jinan, Peoples R China
[14] Heze Municipal Hosp, Dept Neonatol, Heze, Peoples R China
[15] Taian Maternal & Child Hlth Care Hosp, Dept Neonatol, Tai An, Shandong, Peoples R China
[16] Dongying Peoples Hosp, Dept Neonatol, Dongying, Peoples R China
[17] Juxian Peoples Hosp, Dept Neonatol, Rizhao, Peoples R China
[18] Second Peoples Hosp Liaocheng, Dept Neonatol, Liaocheng, Shandong, Peoples R China
[19] Yidu Cent Hosp Weifang, Dept Neonatol, Weifang, Peoples R China
[20] Binzhou Med Univ Hosp, Dept Neonatol, Binzhou, Peoples R China
[21] Maternal & Child Hlth Care Hosp Zaozhuang, Dept Neonatol, Zaozhuang, Peoples R China
[22] Liaocheng Dongchangfu Maternal & Child Hlth Care, Dept Neonatol, Liaocheng, Shandong, Peoples R China
[23] Shandong Univ, Dept Neonatol, Jinan Cent Hosp, Jinan, Peoples R China
[24] Linzi Dist People S Hosp, Dept Neonatol, Zibo, Peoples R China
[25] Shandong First Med Univ, Affiliated Hosp 2, Dept Neonatol, Jinan, Peoples R China
[26] Yantaishan Hosp, Dept Neonatol, Yantai, Peoples R China
[27] Jinan Second Maternal & Child Hlth Hosp, Dept Neonatol, Jinan, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2021年 / 11卷
关键词：
thyrotropin; free thyroxine; preterm infant; postmenstrual age; congenital hypothyroidism;
D O I：
10.3389/fendo.2020.585956
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background At present, the relationship between thyrotropin (TSH) and free thyroxine (FT4) in relation to postmenstrual age (PMA) in preterm infants is still unclear, and there is no reliable standard thyroid hormone reference ranges, resulting in different diagnostic criteria for congenital hypothyroidism been used by different newborn screening programs and different countries. Objectives To investigate the relationship between TSH/FT4 and PMA in very preterm infants (VPIs) born with gestational age (GA) Methods A prospective cohort study was performed on VPIs born with GA<32 weeks and born in or transferred to the 27 neonatal intensive care units from January 1, 2019 to December 31, 2019. Serial TSH and FT4 values were measured at the end of each week during the first month after birth and also at PMA36 weeks, PMA40 weeks and at discharge, respectively. The 2.5th, 5th, 50th, 95th, and 97.5th percentiles of TSH and FT4 of different PMA groups were calculated to draw the percentile charts based on PMA. Results 1,093 preterm infants were included in this study. The percentile charts of TSH and FT4 levels based on PMA were drawn respectively, and the result indicated that the percentile charts of TSH values were gradually increased initially and then decreased with increasing PMA. The 97.5th percentile chart reached the peak at PMA30 weeks (17.38 mu IU/ml), and then decreased gradually, reaching the same level as full-term infants (9.07 mu IU/ml) at PMA38-40 weeks. The 2.5th percentile chart of FT4 was at its lowest point at PMA26-27 weeks (5.23pmol/L), then increased slowly with PMA and reached the same level as full-term infants at PMA38-40 weeks (10.87pmol/L). At PMA36 weeks, the reference intervals of the 2.5th to 97.5th percentiles of TSH and FT4 were 1.18-12.3 mu IU/ml and 8.59-25.98pmol/L, respectively. Conclusion The percentile charts of TSH and FT4 in VPIs showed characteristic change with PMA. The results prompt that age-related cutoffs, instead of a single reference range, might be more useful to explain the thyroid function of VPIs. And repeated screening is necessary for preterm infants.
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页数：9
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