Performance Evaluation of Leader-Follower-Based Mobile Molecular Communication Networks for Target Detection Applications

被引:64
|
作者
Nakano, Tadashi [1 ]
Okaie, Yutaka [1 ]
Kobayashi, Shouhei [2 ]
Koujin, Takako [2 ]
Chan, Chen-Hao [3 ]
Hsu, Yu-Hsiang [3 ]
Obuchi, Takuya [4 ]
Hara, Takahiro [4 ]
Hiraoka, Yasushi [1 ]
Haraguchi, Tokuko [2 ]
机构
[1] Osaka Univ, Grad Sch Frontier Biosci, Osaka 5650871, Japan
[2] Natl Inst Informat & Commun Technol, Kobe, Hyogo 6512492, Japan
[3] Natl Taiwan Univ, Inst Appl Mech, Taipei 106, Taiwan
[4] Osaka Univ, Grad Sch Informat Sci & Technol, Osaka 5650871, Japan
关键词
Mobile molecular communication network; bio-nanomachine; leader-follower model; collective behavior; target detection; targeted drug delivery; haptotaxis; CELL-CELL COMMUNICATION; EXTRACELLULAR-MATRIX; DRUG-DELIVERY; IN-VIVO; MODEL; MIGRATION; NANONETWORKS; INTEGRIN; TRACKING; SYSTEMS;
D O I
10.1109/TCOMM.2016.2628037
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper proposes a leader-follower-based model of mobile molecular communication networks for target detection applications. The proposed model divides the application functionalities of molecular communication networks into two types of mobile bio-nanomachine: leader and follower bio-nanomachines. Leader bio-nanomachines distribute in the environment to detect a target and create an attractant gradient around the target. Follower bio-nanomachines move according to the attractant gradient established by leader bio-nanomachines; they approach the target and perform necessary functionalities, such as releasing drug molecules. This paper develops mathematical expressions for the proposed model, describes wet laboratory experiments designed to estimate model parameters, and performs biologically realistic computer simulation experiments to evaluate the performance of the proposed model. The main contributions of this paper are to demonstrate the functional division of molecular communication networks, which will facilitate the design and development of molecular communication networks. Furthermore, insight into the application-level performance of molecular communication networks will be provided based on the proposed model.
引用
收藏
页码:663 / 676
页数:14
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