Rewiring of hindlimb corticospinal neurons after spinal cord injury

被引：142

作者：

Ghosh, Arko ^{[1
,4
]}

Haiss, Florent ^{[2
]}

Sydekum, Esther ^{[1
,3
]}

Schneider, Regula ^{[1
,4
]}

Gullo, Miriam ^{[1
,4
]}

Wyss, Matthias T. ^{[2
]}

Mueggler, Thomas ^{[1
,3
]}

Baltes, Christof ^{[1
,3
]}

Rudin, Markus ^{[1
,2
,3
]}

Weber, Bruno ^{[2
]}

Schwab, Martin E. ^{[1
,4
]}

机构：

[1] Swiss Fed Inst Technol, Zurich, Switzerland

[2] Univ Zurich, Inst Pharmacol & Toxicol, Zurich, Switzerland

[3] Univ Zurich, Inst Biomed Engn, Zurich, Switzerland

[4] Univ Zurich, Brain Res Inst, Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

PRIMARY SOMATOSENSORY CORTEX; PYRAMIDAL TRACT CELLS; MOTOR CORTEX; ADULT-RATS; PLASTICITY; REGENERATION; CONNECTIONS; STIMULATION; ACTIVATION; RESPONSES;

D O I：

10.1038/nn.2448

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Little is known about the functional role of axotomized cortical neurons that survive spinal cord injury. Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function. Using retrograde tracers, we found that axotomized corticospinal axons from the hindlimb sensorimotor cortex sprouted in the cervical spinal cord. Mapping of these neurons revealed the emergence of a new forelimb corticospinal projection from the rostral part of the former hindlimb cortex. Voltage-sensitive dye (VSD) imaging and blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) revealed a stable expansion of the forelimb sensory map, covering in particular the former hindlimb cortex containing the rewired neurons. Therefore, axotomised hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb.

引用

页码：97 / U266

页数：10

共 50 条

[1] Rewiring of hindlimb corticospinal neurons after spinal cord injury
Arko Ghosh
Florent Haiss
Esther Sydekum
Regula Schneider
Miriam Gullo
Matthias T Wyss
Thomas Mueggler
Christof Baltes
Markus Rudin
Bruno Weber
Martin E Schwab
Nature Neuroscience, 2010, 13 : 97 - 104
[2] Corticospinal reorganization after spinal cord injury
Oudega, Martin
Perez, Monica A.
JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (16): : 3647 - 3663
[3] Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury
Nakamura, Yuka
Ueno, Masaki
Niehaus, Jesse K.
Lang, Richard A.
Zheng, Yi
Yoshida, Yutaka
JOURNAL OF NEUROSCIENCE, 2021, 41 (50): : 10247 - 10260
[4] PLASTICITY IN THE CORTICOSPINAL SYSTEM AFTER SPINAL CORD INJURY
Perez, Monica
JOURNAL OF NEUROTRAUMA, 2015, 32 (12) : A130 - A131
[5] DEATH OF CORTICOSPINAL NEURONS AFTER SPINAL-CORD TRANSECTION
FERINGA, ER
VAHLSING, HL
SMITH, BE
LENHART, TM
NEUROLOGY, 1982, 32 (04) : A70 - A70
[6] ASSESSMENT OF SPINAL-CORD INJURY BY COUNTING CORTICOSPINAL AND RUBROSPINAL NEURONS
MIDHA, R
FEHLINGS, MG
TATOR, CH
SAINTCYR, JA
GUHA, A
BRAIN RESEARCH, 1987, 410 (02) : 299 - 308
[7] ASSESSMENT OF SPINAL-CORD INJURY BY COUNTING CORTICOSPINAL AND RUBROSPINAL NEURONS
MIDHA, R
MICHAEL, G
EEHLINGS, CH
TATOR, JA
SAINTCYR
GUHA, A
CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE, 1987, 10 (04): : B108 - B108
[8] Corticospinal neuroprostheses to restore locomotion after spinal cord injury
Borton, David
Bonizzato, Marco
Beauparlant, Janine
DiGiovanna, Jack
Moraud, Eduardo M.
Wenger, Nikolaus
Musienko, Pavel
Minev, Ivan R.
Lacour, Stephanie P.
Millan, Jose del R.
Micera, Silvestro
Courtine, Gregoire
NEUROSCIENCE RESEARCH, 2014, 78 : 21 - 29
[9] Increased close appositions between corticospinal tract axons and spinal sympathetic neurons after spinal cord injury in rats
Pan, BH
Kim, EJ
Schramm, LP
JOURNAL OF NEUROTRAUMA, 2005, 22 (12) : 1399 - 1410
[10] THE ORTHOGRADE FLOW OF TRITIATED PROLINE IN CORTICOSPINAL NEURONS AT VARIOUS AGES AND AFTER SPINAL-CORD INJURY
FERINGA, ER
VAHLSING, HL
DAUSER, RC
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1984, 47 (09): : 917 - 920

← 1 2 3 4 5 →