TKI258 (CHIR-258) selectively inhibits FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome.

被引:0
|
作者
Chase, Andrew [1 ]
Grand, Francis H. [1 ]
Cross, Nicholas C. P. [1 ]
机构
[1] Univ Southampton, Wessex Reg Genet Lab, Salisbury, Wilts, England
关键词
D O I
10.1182/blood.V108.11.2699.2699
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2699
引用
收藏
页码:763A / 763A
页数:1
相关论文
共 37 条
  • [31] Screening of Drugs to Treat 8p11 Myeloproliferative Syndrome Using Patient-Derived Induced Pluripotent Stem Cells with Fusion Gene CEP110-FGFR1
    Yamamoto, Shohei
    Otsu, Makoto
    Matsuzaka, Emiko
    Konishi, Chieko
    Takagi, Haruna
    Hanada, Sachiyo
    Mochizuki, Shinji
    Nakauchi, Hiromitsu
    Imai, Kohzoh
    Tsuji, Kohichiro
    Ebihara, Yasuhiro
    PLOS ONE, 2015, 10 (03):
  • [32] Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder:: The first fusion gene involving BCR but not ABL
    Fioretos, T
    Panagopoulos, I
    Lassen, C
    Swedin, A
    Billström, R
    Isaksson, M
    Strömbeck, B
    Olofsson, T
    Mitelman, F
    Johansson, B
    GENES CHROMOSOMES & CANCER, 2001, 32 (04): : 302 - 310
  • [33] Allogeneic hematopoietic stem cell transplantation for 8p11 myeloproliferative syndrome with BCR-FGFR1 gene rearrangement: a case report and literature review
    Yoshinobu Konishi
    Tadakazu Kondo
    Kensuke Nakao
    Kohusuke Asagoe
    Yasuyuki Otsuka
    Momoko Nishikori
    Masakatsu Hishizawa
    Kouhei Yamashita
    Akifumi Takaori-Kondo
    Bone Marrow Transplantation, 2019, 54 : 326 - 329
  • [34] Allogeneic hematopoietic stem cell transplantation for 8p11 myeloproliferative syndrome with BCR-FGFR1 gene rearrangement: a case report and literature review
    Konishi, Yoshinobu
    Kondo, Tadakazu
    Nakao, Kensuke
    Asagoe, Kohusuke
    Otsuka, Yasuyuki
    Nishikori, Momoko
    Hishizawa, Masakatsu
    Yamashita, Kouhei
    Takaori-Kondo, Akifumi
    BONE MARROW TRANSPLANTATION, 2019, 54 (02) : 326 - 329
  • [35] TWO NEW OBSERVATIONS OF 8p11 MYELOPROLIFERATIVE SYNDROME WITH t(6;8)(q27;p11) AND t(8;9) (p1 1;q34) TRANSLOCATIONS, FGFR1 GENE DELETION, AND EV1-1 GENE HYPEREXPRESSION: THEORETICAL AND CLINICAL ASPECTS
    Gindina, T. L.
    Mamaev, N. N.
    Baikov, V. V.
    Barkhatov, I. M.
    Gorbunova, A. V.
    Bondarenko, S. N.
    Slesarchuk, O. A.
    Averyanova, M. Yu.
    Uspenskaya, O. S.
    Afanasyev, B. V.
    GEMATOLOGIYA I TRANSFUZIOLOGIYA, 2013, 58 (04): : 13 - 17
  • [36] 8p11 myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: A case report and review of the literature
    Kim, Seon Young
    Oh, Bora
    She, Cha Ja
    Kim, Hyun Kyung
    Jeon, Yoon Kyung
    Shin, Myung-Geun
    Yoon, Sung-Soo
    Lee, Dong Soon
    LEUKEMIA RESEARCH, 2011, 35 (05) : E30 - E34
  • [37] PKC412 inhibits the ZNF198-FGFR1 fusion tyrosine kinase and is efficacious in treatment of t(8;13)(p11;q12) associated stem cell myeloproliferative disease.
    Chen, J
    DeAngelo, DJ
    Kutok, JL
    Williams, IR
    Lee, BH
    Wadleigh, M
    Duclos, N
    Cohen, S
    Adelsperger, J
    Okabe, R
    Coburn, A
    Galinsky, I
    Huntly, BJP
    Cohen, P
    Meyer, T
    Fabbro, D
    Banerji, L
    Griffin, JD
    Xiao, S
    Fletcher, JA
    Stone, RM
    Gilliland, DG
    BLOOD, 2004, 104 (11) : 698A - 698A