Construction and development of a new single-column simulated moving bed system on the laboratory scale

被引：7

作者：

Buhlert, Kerstin ^{[1
]}

Lehr, Markus ^{[2
]}

Jungbauer, Alois ^{[1
]}

机构：

[1] Univ Bodenkultur Wien, Dept Biotechnol, A-1190 Vienna, Austria

[2] Vogelbusch GmbH, Vienna, Austria

来源：

JOURNAL OF CHROMATOGRAPHY A | 2009年 / 1216卷 / 50期

关键词：

Simulated moving bed; Single column; Laboratory scale; Scale down; Embedded distributor; SEPARATION; CHROMATOGRAPHY; COUNTERCURRENT;

D O I：

10.1016/j.chroma.2009.10.010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Simulated moving bed (SMB) chromatography combines high productivity and high purities with reduced buffer consumption. We have developed a laboratory scale single column SMB (SC-SMB) unit with all four separation zones in one column. Distributors embedded within the chromatographic medium allow introduction and withdrawal of liquid between the zones. This single column unit exhibits homogenous packing in all zones, reduced headspace, less complex tubing, fewer valves, and almost undisturbed plug flow between the separation zones. The separation performance of the column was investigated with two different binary model mixtures. Furthermore, the SC-SMB unit is operated with a modified AKTA Explorer workstation, which has been specifically developed for the handling of biological fluids. (C) 2009 Elsevier B.V. All rights reserved

引用

页码：8778 / 8786

页数：9

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