Prostate cancer detection with 3-T MRI: Comparison of diffusion-weighted and T2-weighted imaging

Objective: To compare the clinical value of diffusion-weighted (DW) and T2-weighted (T2W) imaging in detecting prostate cancer using a 3-Tesla (3 T) magnetic resonance (MR) system. Materials and methods: Thirty-seven patients with suspected prostate cancer underwent T2W and DW imaging at 3 T using an 8-channel phased-array coil. These images and apparent diffusion coefficient (ADC) maps were read retrospectively and blindly. The results were compared with histopathologic findings, and receiver operating characteristic (ROC) analysis was used to compare the cancer detection performance of T2W and DW imaging. Results: The areas under the ROC curves for DW imaging and T2W imaging were 0.89 and 0.82, respectively. The performance of DW imaging in prostate cancer detection was significantly better than that of T2W imaging (P = 0.0371). Conclusion: With a 3 T MR system, the performance of DW imaging in detecting prostate cancer was better than that of T2W imaging. DW imaging appears to be a robust and reliable method to examine the whole prostate within an acceptable scan time in clinical settings. (c) 2006 Elsevier Ireland Ltd. All rights reserved.