Cefodizime enhances phagocytosis and intracellular killing of Staphylococcus aureus but does not influence polymorphonuclear leukocytes response to fMLP stimulation

被引：3
|
作者：
Bialasiewicz, P
Stolarek, R
Wejner, P
Piasecka, G
Dutkiewicz, B
Mikucki, J
Nowak, D
机构：
[1] Med Univ Lodz, Dept Physiol, PL-90131 Lodz, Poland
[2] Med Univ Lodz, Dept Microbiol, PL-90235 Lodz, Poland
来源：
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 2000年 / 22卷 / 07期
关键词：
Cefodizime; polymorphonuclear leukocytes; intracellular calcium changes; degranulation; hydrogen peroxide production; chemiluminescence; phagocytosis; intracellular killing of bacteria;
D O I：
10.1016/S0192-0561(00)00019-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The influence of Cefodizime (CDZ) on in vitro activity of polymorphonuclear leukocytes (PMNL) from healthy subjects was assessed. Preincubation with CDZ enhanced phagocytosis and intracellular killing of Staphylococcus aureus by PMNL. Contrary to numerous clinical reports, no significant effect of CDZ preincubation on PMNL response to n-formyl-methionyl-leucyl-phenylalanine was found with respect to intracellular calcium changes, degranulation, hydrogen peroxide production, and chemiluminescence. These results suggest that augmented microbicidal activity of PMNL is not related to the enhanced production of reactive oxygen species in healthy subjects. (C) 2000 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.
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页码：557 / 566
页数：10
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