Central corneal thickness in the European Glaucoma Prevention Study

被引：44

作者：

Pfeiffer, Norbert ^{[1
]}

Torri, Valter ^{[1
]}

Miglior, Stefano ^{[1
]}

Zeyen, Thierry ^{[1
]}

Adamsons, Ingrid ^{[1
]}

Cunha-Vaz, Jose ^{[1
]}

Linsen, Marie-Claire ^{[1
]}

Pellicci, Liliana ^{[1
]}

Janssens, Andre ^{[1
]}

van der Veken, Anja ^{[1
]}

Nerinckx, Fanny ^{[1
]}

Boeyden, Vicky ^{[1
]}

Kestelijn, Philippe ^{[1
]}

Van den Abeele, Kathleen ^{[1
]}

Jacobs, Kristin ^{[1
]}

Decock, Christian ^{[1
]}

Goethals, Marc ^{[1
]}

Pourjavan, Sayeh ^{[1
]}

Maris, Karolien ^{[1
]}

Kersten, Inga ^{[1
]}

Vogel, Annette ^{[1
]}

Herkel, Ulrike ^{[1
]}

Schwenn, Oliver ^{[1
]}

Maser-Wahle, Marlene ^{[1
]}

Funk, Jens ^{[1
]}

Schmidt, Beate ^{[1
]}

Akbariyeh, Nuschin ^{[1
]}

Burk, Reinhard ^{[1
]}

Thomsen, Andrea ^{[1
]}

Grehn, Franz ^{[1
]}

Marquardt, Dirk ^{[1
]}

Orzalesi, Nicola ^{[1
]}

Miglior, Stefano ^{[1
]}

Rossetti, Luca ^{[1
]}

Ferrante, Maurizio ^{[1
]}

Mandelli, Luciana ^{[1
]}

Bertoni, Giancarlo ^{[1
]}

Blini, Mirella ^{[1
]}

De Molfetta, Massimo ^{[1
]}

Bonomi, Luciano ^{[1
]}

Morbio, Roberta ^{[1
]}

Marraffa, Michele ^{[1
]}

Maraini, Giovanni ^{[1
]}

Gandolfi, Stefano ^{[1
]}

Williams, Sally ^{[1
]}

Cimino, Luca ^{[1
]}

Dondi, Patrizia ^{[1
]}

Lumbroso, Bruno ^{[1
]}

Marini, Gianluca ^{[1
]}

Centofanti, Marco ^{[1
]}

机构：

[1] Univ Hosp Mainz, Dept Ophthalmol, D-55131 Mainz, Germany

来源：

OPHTHALMOLOGY | 2007年 / 114卷 / 03期

关键词：

D O I：

10.1016/j.ophtha.2006.07.039

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To measure central corneal thickness (CCT) within the participants of the European Glaucoma Prevention Study (EGPS). This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma. Design: Randomized, double-masked, controlled, observational clinical trial. Participants: Eight hundred fifty-four of 1077 ocular hypertensive participants within the EGPS were investigated. Four hundred twenty-nine patients were treated with dorzolamide and 425 patients received placebo. Intervention: Treatment with dorzolamide or placebo (the vehicle of dorzolamide) in 1 or both eyes. Main Outcome Measures: Central corneal thickness as measured by ultrasound pachymetry (DGH-500 Pachette; DGH Technologies, Exton, PA). The CCT measurements were obtained in the morning before measuring IOP. Five measurements were taken from each eye of each patient within 5 minutes of application of anesthetic eye drops. Results: Mean CCT was 572.6 +/- 37.4 mu m (range, 458.5-695.6 mu m). The CCT was higher in younger patients, male patients, and diabetic patients. Mean CCTs for the 429 patients receiving dorzolamide were 574.2 +/- 38.48 mu m (range, 458.5-695.6 mu m) and 571.0 +/- 36.21 mu m (469.7-690.1 mu m) for the 425 patients receiving placebo (P = 0.205). Central corneal thickness did not correlate with refraction, baseline IOP, or systemic hypertension. Conclusion: Central corneal thickness measurements within the EGPS were greater than those reported in other studies of normal eyes without ocular hypertension. Larger CCT measurements correlated with male gender, younger age, and diabetes.

引用

页码：454 / 459

页数：6

共 50 条

[1] Central corneal thickness in the European glaucoma prevention study (EGPS)
Pfeiffer, N
Troost, A
Kersten-Gomez, I
Miglior, S
Torri, V
Zeyen, T
Cunha-Vaz, J
Adamsonson, I
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
[2] Central corneal thickness in a subgroup of the European Glaucoma Prevention Study
Vogel, AI
Kersten-Gomez, I
Troost, R
Pourjavan, S
Bertoni, G
Gandolfi, S
Zeyen, T
Miglior, S
Pfeiffer, N
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U370 - U370
[3] Central corneal thickness in glaucoma
Sng, Chelvin C. A.
Ang, Marcus
Barton, Keith
[J]. CURRENT OPINION IN OPHTHALMOLOGY, 2017, 28 (02) : 120 - 126
[4] Central corneal thickness in pediatric glaucoma
Lopes, Joao F.
Wilson, Richard P.
Alvim, Heryberto S.
Shields, Carol L.
Shields, Jerry A.
Calhoun, Joseph
Fontanarosa, Joann
Steinmann, William C.
[J]. JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS, 2007, 44 (02) : 112 - 117
[5] Central corneal thickness and risk of glaucoma
Foster, PJ
Machin, D
Gazzard, G
Husain, R
Devereux, JG
Chew, PT
Oen, FT
Khaw, PT
Seah, SK
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U455 - U455
[6] Central Corneal Thickness in Juvenile Glaucoma
Moghimi, Sasan
Nazari, Rahman
Fakhraie, Ghasem
Kiarudi, Mohammad Yaser
Eslami, Yadollah
Zarei, Reza
Vakil, Narges Zand
Rafizadeh, Seyed Mohsen
[J]. IRANIAN JOURNAL OF OPHTHALMOLOGY, 2011, 23 (03): : 15 - 20
[7] Central corneal thickness in congenital glaucoma
Wygnanski-Jaffe, Tamara
Barequet, Irina S.
[J]. CORNEA, 2006, 25 (08) : 923 - 925
[8] Central corneal thickness in patients with and without glaucoma
Shafranov, G
Soltau, JB
Harmon, H
Shields, MB
Zimmerman, TJ
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2000, 41 (04) : S515 - S515
[9] The thick and thin of the central corneal thickness in glaucoma
Belovay, Graham W.
Goldberg, Ivan
[J]. EYE, 2018, 32 (05) : 915 - 923
[10] Central corneal thickness as a risk factor for glaucoma
Mehdizadeh, Alireza
Hoseinzadeh, Amin
Fazelzadeh, Afsoon
[J]. MEDICAL HYPOTHESES, 2007, 69 (06) : 1205 - 1207

← 1 2 3 4 5 →