Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity

被引：38
|
作者：
Steinert, Elizabeth M. [1 ]
Vasan, Karthik [1 ]
Chandel, Navdeep S. [1 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Med Biochem & Mol Genet, Chicago, IL 60611 USA
来源：
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 | 2021年 / 39卷
关键词：
TCA cycle; epigenetics; inflammation; ROS; acetyl-CoA; L-2HG; L-2-hydroxyglutarate; AEROBIC GLYCOLYSIS; TRANSCRIPTION FACTOR; EFFECTOR FUNCTION; MEMORY DEVELOPMENT; TCA CYCLE; ACTIVATION; REQUIRES; CHECKPOINT; SURVIVAL; BALANCE;
D O I：
10.1146/annurev-immunol-101819-082015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.
引用
收藏
页码：395 / 416
页数：22
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