Stereospecific preparation of an excitatory amino acid antagonist with D-hydantoinase from Agrobacterium tumefaciens as a biocatalyst

被引：1
|
作者：
Durham, DR
Weber, JE
机构：
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1996年 / 62卷 / 02期
关键词：
D O I：
10.1128/AEM.62.2.739-742.1996
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Extracts of Agrobacterium tumefaciens were used to mediate the stereospecific conversion of a racemic hydantoin to a carbamyl D-amino acid derivative, which is a precursor to (2R,4R,5S)-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (ACPA). ACPA has therapeutic value as an excitatory amino acid antagonist.
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页码：739 / 742
页数：4
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