The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

被引：219

作者：

Abella, Vanessa ^{[1
,2
]}

Scotece, Morena ^{[1
]}

Conde, Javier ^{[1
]}

Gomez, Rodolfo ^{[1
]}

Lois, Ana ^{[1
]}

Pino, Jesus ^{[3
]}

Gomez-Reino, Juan J. ^{[1
]}

Lago, Francisca ^{[4
]}

Mobasheri, Ali ^{[5
,6
,7
,8
]}

Gualillo, Oreste ^{[1
]}

机构：

[1] Univ Santiago, NEIRID Lab Neuroendocrine Interact Rheumatol & In, SERGAS Serv Galego Saude, Res Lab 9,Inst Med Res IDIS,Clin Hosp, Trav Choupana Sn, Santiago De Compostela 15706, Spain

[2] Univ A Coruna, Fac Ciencias, Dept Biol Celular & Mol, Campus De A Coruna, Spain

[3] Univ Santiago, Clin Hosp, Div Orthopaed Surg & Traumatol, SERGAS, Santiago De Compostela, Spain

[4] Univ Santiago, Mol & Cellular Cardiol Lab, Inst Med Res IDIS, SERGAS Serv Galego Saude,Res Lab 7,Clin Hosp, Santiago De Compostela, Spain

[5] Univ Surrey, D BOARD European Consortium Biomarker Discovery, Sch Vet Med, Dept Vet Preclin Sci,Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey, England

[6] Univ Nottingham, Queens Med Ctr, Arthrit Res UK Ctr Sport Exercise & Osteoarthrit, Arthrit Res UK Pain Ctr,Med Res Council, Nottingham NG7 2RD, England

[7] Univ Nottingham, Arthrit Res UK Ctr Musculoskeletal Ageing Res, Nottingham NG7 2RD, England

[8] King Abdulaziz Univ, Fac Appl Med Sci, KFMRC, CEGMR, Jeddah 21413, Saudi Arabia

来源：

BIOMARKERS | 2015年 / 20卷 / 08期

关键词：

kidney diseases; Adipokines; immunity; rheumatic diseases; adipose tissue; GELATINASE-ASSOCIATED LIPOCALIN; ADAPTIVE IMMUNE-RESPONSES; INSULIN-RESISTANCE; LUPUS NEPHRITIS; IN-VITRO; EXPRESSION; IRON; PROTEIN; RECEPTOR; MOUSE;

D O I：

10.3109/1354750X.2015.1123354

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism.

引用

页码：565 / 571

页数：7

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