Trafficking of PfExp1 to the parasitophorous vacuolar membrane of Plasmodium falciparum is independent of protein folding and the PTEX translocon

被引：10
|
作者：
Tribensky, Anke [1 ]
Graf, Andreas W. [1 ]
Diehl, Mathias [1 ]
Fleck, Wiebke [1 ]
Przyborski, Jude M. [1 ]
机构：
[1] Univ Marburg, Dept Parasitol, Marburg, Germany
来源：
CELLULAR MICROBIOLOGY | 2017年 / 19卷 / 05期
关键词：
Exp1; malaria; parasitophorous vacuole; protein folding; PTEX; RED-BLOOD-CELLS; MALARIA PARASITES; HOST ERYTHROCYTE; INFECTED ERYTHROCYTES; TARGETING SIGNAL; EXPORT; TRANSPORT; COMPARTMENT; VIRULENCE; INSERTION;
D O I：
10.1111/cmi.12710
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Having entered the mature human erythrocyte, the malaria parasite survives and propagates within a parasitophorous vacuole, a membrane-bound compartment separating the parasite from the host cell cytosol. The bounding membrane of this vacuole, referred to as the parasitophorous vacuolar membrane (PVM), contains parasite-encoded proteins, but how these membrane proteins are trafficked to the PVM remains unknown. Here, we have studied the trafficking of PfExp1 to the PVM. We find that trafficking of PfExp1 to the PVM is independent of the folding state of the protein and also continues unabated upon inactivation of the PVM translocon Plasmodium Translocon of Exported proteins (PTEX). Our data strongly suggest that the trafficking of membrane proteins to the PVM occurs by as yet unknown mechanism, potentially unique to Plasmodium.
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页数：9
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