Sorting out the cellular functions of sorting nexins

被引：333
|
作者：
Worby, CA [1 ]
Dixon, JE [1 ]
机构：
[1] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 12期
关键词：
D O I：
10.1038/nrm974
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.
引用
收藏
页码：919 / 931
页数：13
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