Mechanisms of pluripotency maintenance in mouse embryonic stem cells

被引：24

作者：

Chen, Chen-Yun ^{[1
]}

Cheng, Yuan-Yuan ^{[1
,2
]}

Yen, Christopher Y. T. ^{[1
]}

Hsieh, Patrick C. H. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Acad Sinica, Inst Biomed Sci, IBMS, Rm 417,128 Acad Rd,Sect 2, Taipei 115, Taiwan

[2] Natl Def Med Ctr, Inst Life Sci, Taipei 114, Taiwan

[3] Natl Taiwan Univ & Hosp, Inst Med Genom & Prote, Inst Clin Med, Taipei 100, Taiwan

[4] Natl Taiwan Univ & Hosp, Dept Surg, Taipei 100, Taiwan

[5] Natl Cheng Kung Univ, Inst Clin Med, Tainan 701, Taiwan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 10期

关键词：

Pluripotency; Mouse embryonic stem cells; Transcriptional regulation; Epigenetic regulation; TRANSCRIPTIONAL REGULATORY CIRCUITRY; CHROMATIN REMODELING COMPLEX; POLYCOMB-GROUP PROTEINS; SELF-RENEWAL; DNA METHYLATION; GENE-EXPRESSION; SYNERGISTIC ACTION; NONCODING RNAS; GROUND-STATE; XIST GENE;

D O I：

10.1007/s00018-016-2438-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse embryonic stem cells (mESCs), characterized by their pluripotency and capacity for self-renewal, are driven by a complex gene expression program composed of several regulatory mechanisms. These mechanisms collaborate to maintain the delicate balance of pluripotency gene expression and their disruption leads to loss of pluripotency. In this review, we provide an extensive overview of the key pillars of mESC pluripotency by elaborating on the various essential transcription factor networks and signaling pathways that directly or indirectly support this state. Furthermore, we consider the latest developments in the role of epigenetic regulation, such as noncoding RNA signaling or histone modifications.

引用

页码：1805 / 1817

页数：13

共 50 条

[1] Mechanisms of pluripotency maintenance in mouse embryonic stem cells
Chen-Yun Chen
Yuan-Yuan Cheng
Christopher Y. T. Yen
Patrick C. H. Hsieh
[J]. Cellular and Molecular Life Sciences, 2017, 74 : 1805 - 1817
[2] Distinct requirements for the establishment and maintenance of sustainable pluripotency of mouse embryonic stem cells
Konishi, Riyo
[J]. MECHANISMS OF DEVELOPMENT, 2017, 145 : S166 - S166
[3] Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus
Okumura, A
Machii, K
Azuma, S
Toyoda, Y
Kyuwa, S
[J]. JOURNAL OF VIROLOGY, 1996, 70 (06) : 4146 - 4149
[4] Effects of Fruquintinib on the Pluripotency Maintenance and Differentiation Potential of Mouse Embryonic Stem Cells
Zeng, Hanyi
Peng, Fanke
Wang, Jiachen
Meng, Ru
Zhang, Jun
[J]. CELLULAR REPROGRAMMING, 2021, 23 (03) : 180 - 190
[5] Maintenance of Pluripotency in Mouse Embryonic Stem Cells Cultivated in Stirred Microcarrier Cultures
Marinho, Paulo A. N.
Fernandes, Aline M.
Cruz, Juliana C.
Rehen, Stevens K.
Castilho, Leda R.
[J]. BIOTECHNOLOGY PROGRESS, 2010, 26 (02) : 548 - 555
[6] Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells
Yamane, Mariko
Fujii, Setsuko
Ohtsuka, Satoshi
Niwa, Hitoshi
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 468 (04) : 826 - 831
[7] Pluripotency maintenance mechanism of embryonic stem cells and reprogramming
Shinji Masui
[J]. International Journal of Hematology, 2010, 91 : 360 - 372
[8] Pluripotency maintenance mechanism of embryonic stem cells and reprogramming
Masui, Shinji
[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2010, 91 (03) : 360 - 372
[9] The maintenance of pluripotency following laser direct-write of mouse embryonic stem cells
Raof, Nurazhani Abdul
Schiele, Nathan R.
Xie, Yubing
Chrisey, Douglas B.
Corr, David T.
[J]. BIOMATERIALS, 2011, 32 (07) : 1802 - 1808
[10] Molecular mechanisms underlying pluripotency of embryonic stem cells
Yamanaka, S
[J]. SEIKAGAKU, 2006, 78 (01): : 27 - 33

← 1 2 3 4 5 →