Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro

被引：8

作者：

Zhang, Ming ^{[1
]}

Zhang, Yuwei ^{[2
]}

Huang, Qiqi ^{[1
]}

Duan, Hui ^{[1
]}

Zhao, Guodong ^{[1
]}

Liu, Lei ^{[1
]}

Li, Yuxin ^{[1
]}

机构：

[1] Northeast Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China

[2] Shandong Hongjitang Pharmaceut Grp Co Ltd, Chinese Med Res Inst, Jinan 250103, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2021年 / 35卷

关键词：

Sophora alopecuroides L; Leguminosae; Flavonoids; Insulin resistance; PTP1B;

D O I：

10.1016/j.bmcl.2021.127775

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seventeen flavonoids (1-17) were isolated from Sophora alopecuroides L.. Compounds 1 and 2 were new compounds, and compounds 5, 8, 11, 12, and 17 were isolated from S. alopecuroides for the first time. The sources of compounds 1 and 2 were determined from the seeds of S. alopecuroides by UPLC-QE-Orbitrap-MS, and compounds 1, 2, 7, 13, 14, 15, 16, and 17 were proven to improve the insulin resistance of C2C12 myotubes and significantly increase glucose consumption levels. Among them, compounds 1, 2, 13, 14, 16, and 17 could bind to protein tyrosine phosphatase 1B (PTP1B), thereby significantly inhibiting the enzyme activity of PTP1B. Compound 2 had the strongest inhibitory effect, with an inhibition rate of 95.22% at 0.1 mu g mL(-1).

引用

页数：7

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