Late Stent Thrombosis After Drug-Coated Balloon Coronary Angioplasty for In-Stent Restenosis A Case Report

被引：2
|
作者：
Wang, Wenjun [1 ,2 ,3 ,4 ,5 ,6 ]
Wang, Bailu [7 ]
Chen, Yuguo [1 ,2 ,3 ,4 ,5 ,6 ]
Wei, Shujian [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Emergency, 107 Wen Hua Xi Rd, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Chest Pain Ctr, 107 Wen Hua Xi Rd, Jinan 250012, Shandong, Peoples R China
[3] Shandong Univ, Inst Emergency & Crit Care Med Shandong Univ, Cheeloo Coll Med,Qilu Hosp, Clin Res Ctr Emergency & Crit Care Med Shandong P, Jinan, Peoples R China
[4] Shandong Univ, Cheeloo Coll Med, Key Lab Emergency & Crit Care Med Shandong Prov, Qilu Hosp,Key Lab Cardiopulm Cerebral Resuscitat, Jinan, Peoples R China
[5] Chinese Minist Hlth, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan, Peoples R China
[6] Shandong Univ, Chinese Acad Med Sci, Cheeloo Coll Med, Qilu Hosp,State & Shandong Prov Joint Key Lab Tra, Jinan, Peoples R China
[7] Shandong Univ, Cheeloo Coll Med, Clin Trial Ctr, Qilu Hosp, Jinan, Peoples R China
来源：
INTERNATIONAL HEART JOURNAL | 2021年 / 62卷 / 01期
基金：
国家重点研发计划;
关键词：
Coronary artery disease; Gene mutation; Antiplatelet strategy; Myocardial infarction; POLYMORPHISMS;
D O I：
10.1536/ihj.20-309
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 41-year-old woman with chest pain for 6 hours was admitted to our chest pain center, presenting with acute myocardial infarction. Coronary angiography showed acute total occlusion in the proximal left anterior descending artery due to late stent thrombosis. After thrombus aspiration and intracoronary administration of 0.5 mg tirofiban, repeated angiography showed that no obvious residual stenosis remained. The patient underwent drug-coated balloon angioplasty 69 days ago and was then administered dual antiplatelet treatment (aspirin and clopidogrel) uninterruptedly. Genetic testing found that both cytochrome P450 2C19 (CYP2C19) (G681A) and glycoprotein Ia (GPIa) (C807T, G873A) were hybrid mutant types, demonstrating that the patient was possibly resistant to clopidogrel and aspirin simultaneously. Thus, clopidogrel was replaced by ticagrelor and no more cardiovascular adverse events occurred during the 2-year follow-up.
引用
收藏
页码：171 / 174
页数：4
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