Primary mediastinal large B-cell lymphoma in a patient on Fingolimod for relapsing-remitting multiple sclerosis

被引：5
|
作者：
Chacko, Joseph A. [1 ]
Strati, Paolo [2 ]
Stout, Paul W. [3 ]
Archer, Robert L. [1 ]
Baltz, Brad P. [4 ]
Chacko, Joseph G. [1 ]
机构：
[1] Univ Arkansas Med Sci, Coll Med, Little Rock, AR 72205 USA
[2] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Lymphoma Myeloma, Houston, TX 77030 USA
[3] Arkansas Pathol Associates PA, Little Rock, AR USA
[4] CHI St Vincent Infirm, Hematol Oncol Div, Little Rock, AR USA
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 49卷
关键词：
Multiple sclerosis; Fingolimod; Lymphoma; Primary mediastinal large B-cell lymphoma; CD30;
D O I：
10.1016/j.msard.2021.102776
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: There are multiple case reports in the literature describing an association between fingolimod and cutaneous neoplasms. Objective: Investigate and report a case of a primary mediastinal large B-cell lymphoma in a patient on fingolimod for Relapsing-Remitting Multiple Sclerosis (RRMS). Methods: Case Report. Results: The patient developed a primary mediastinal large B-cell lymphoma after seven years of treatment with fingolimod. The patient is currently in complete remission after cessation of treatment, surgical resection, chemotherapy, and radiation therapy. Conclusion: This case report highlights the first primary mediastinal large B-cell lymphoma associated with fingolimod treatment. It should be considered a rare, but potential adverse effect of fingolimod.
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页数：3
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