Mutation of epidermal growth factor receptor gene in adenosquamous carcinoma of the lung

被引：36

作者：

Sasaki, Hidefumi ^{[1
]}

Endo, Katsuhiko ^{[1
]}

Yukiue, Haruhiro ^{[1
]}

Kobayashi, Yoshihiro ^{[1
]}

Yano, Motoki ^{[1
]}

Fujii, Yoshitaka ^{[1
]}

机构：

[1] Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

LUNG CANCER | 2007年 / 55卷 / 01期

关键词：

EGFR; mutation; adenosquamous;

D O I：

10.1016/j.lungcan.2006.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated 26 adenosquamous lung cancer tissues and found that four EGFR mutations were mainly in female and non-smoker lung cancer. However, EGFR mutation at kinase domain was exclusive with K-ras mutation. However, smoking and gender status could affect the occurrence of EGFR mutation. There was no difference in EGFR mutation status if analysis was performed in never smoker female subgroup. (c) 2006 Elsevier Ireland Ltd. AR rights reserved.

引用

页码：129 / 130

页数：2

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