Five Near Full-Length Hepatitis C Virus Sequences Were Identified from HIV Coinfected Injection Drug Users of China

被引：0

作者：

Li, Fan ^{[1
]}

Feng, Yi ^{[1
]}

Ni, Na ^{[1
]}

Hu, Jing ^{[1
]}

Ruan, Yuhua ^{[1
]}

Shao, Yiming ^{[1
]}

Ma, Liying ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 05期

基金：

中国国家自然科学基金;

关键词：

hepatitis C virus; IDUs; near full-length genome; diversity; EVOLUTION; EPIDEMIC;

D O I：

10.1089/aid.2016.0317

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV and hepatitis C virus (HCV) share transmission routes, including contaminated blood transfusion, sexual intercourse, and needle-sharing in injection drug users (IDUs). We obtained five near full-length genome sequences of HCV isolated from five HIV-1-coinfected IDUs in Sichuan and Xinjiang provinces, China. By conducting reconstruction of neighbor-joining phylogenetic tree, our results revealed that the five isolates are of four different genotypes (1b, 3a, 6a, and 6n). The amino acid substitutions (170I) in XJN0021 related to resistant to protease inhibitors (grazoprevir) were also identified. The genetic diversity of these sequences uncovered more complicated transmission situation of HCV among IDUs in China.

引用

页码：496 / 499

页数：4

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