Serial Interferon Gamma Release Assay in Latent Tuberculosis Infection

被引:1
|
作者
Dodig, Slavica [1 ]
Zrinski-Topic, Renata [1 ]
机构
[1] Minist Hlth & Social Welf, Reference Ctr Clin Allergol Children, Srebrnjak Childrens Hosp, Dept Clin Lab Diag, Zagreb, Croatia
来源
LABMEDICINE | 2009年 / 40卷 / 11期
关键词
HEALTH-CARE WORKERS; IGA; BCG; MICE;
D O I
10.1309/LMJ62BPKL7AKRVYJ
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
The aim of this report is to present results of serial interferon-gamma (IFN-gamma) determination (OuantiFERON-TB Gold In-Tube assay) in a 57-year-old BCG-vaccinated female: health care worker with a latent tuberculosis:infection. Increased IFN-gamma, IgA, and anti-thyroglobulin (anti-Tg) autoantibodies were recorded throughout a 13-month follow up. After 13 months the subject was clinically Healthy and free from any signs and symptoms of active tuberculosis. The increased levels of anti-Tg autoantibodies may have been a concurrent process that did not: impair the patient's immune status. Since false positive; IgA could be found in patients suffering from autoimmune thyroid diseases, it could be assumed increased IgA in this subject is a result of the positive interferences of goat anti-IgA antibodies. Although isoniazid prophylexis was not used, tuberculosis did not develop during the, follow-up period. Serial determination of IFN-gamma is necessary due to occupational exposure to tubercle bacilli.
引用
收藏
页码:681 / 682
页数:2
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