Regulation of growth hormone action by gonadal steroids

被引：36
|
作者：
Meinhardt, Udo J.
Ho, Ken K. Y.
机构：
[1] Garvan Inst Med Res, Pituitary Res Unit, Darlinghurst, NSW 2010, Australia
[2] Univ New S Wales, Kensington, NSW 2010, Australia
[3] St Vincents Hosp, Dept Endocrinol, Sydney, NSW 2010, Australia
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2007年 / 36卷 / 01期
关键词：
D O I：
10.1016/j.ecl.2006.11.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sex steroids modulate growth hormone (GH) secretion and action. Estrogen attenuates GH action in a dose- and route-dependent manner by inhibiting GH-regulated endocrine function of the liver. Testosterone amplifies the metabolic action of GH while exhibiting similar but independent effects of its own. The strong modulatory effect of gonadal steroids on GH responsiveness provides insights into the biologic basis of sexual dimorphism in growth, development, and body composition and practical information for the clinical endocrinologist in the treatment of hypopituitary patients.
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页码：57 / +
页数：18
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