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Yonsei Univ, Coll Med,Inst Gastroenterol, Dept Internal Med,Div Gastroenterol, Brain Korea Project Med Sci 21,Seodaemun Ku, Seoul 120752, South Korea Yonsei Univ, Coll Med,Inst Gastroenterol, Dept Internal Med,Div Gastroenterol, Brain Korea Project Med Sci 21,Seodaemun Ku, Seoul 120752, South Korea