Optimization of Fc-mediated effector functions of monoclonal antibodies

被引：99

作者：

Strohl, William R. ^{[1
]}

机构：

[1] Centocor R&D Inc, Antibody Drug Discovery, Radnor, PA 19087 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2009年 / 20卷 / 06期

关键词：

DEPENDENT CELLULAR CYTOTOXICITY; HUMAN IGG1; IN-VIVO; ANTIINFLAMMATORY ACTIVITY; IMMUNOGLOBULIN-G; STRUCTURAL-CHARACTERIZATION; THERAPEUTIC ANTIBODIES; ENGINEERED ANTIBODIES; ENHANCED BINDING; GAMMA-RIIIA;

D O I：

10.1016/j.copbio.2009.10.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The engineering of therapeutic and clinical candidate monoclonal antibodies and Fc fusion proteins is becoming more sophisticated at generating molecules that are better suited to the pharmacological activity required of them. There are at least 14 marketed and clinical candidate antibodies and Fc fusion proteins in which the Fc has been modified, either via changes in amino acid sequence or in glycoforms. Recent research and development activities in Fc engineering to generate 'fit-for-purpose' antibodies and Fc fusion proteins are reviewed.

引用

页码：685 / 691

页数：7

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