Susceptibility of Peromyscus leucopus and Mus musculus to infection with Baylisascaris procyonis

被引:33
|
作者
Sheppard, CH
Kazacos, KR
机构
[1] Dept. of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette
关键词
D O I
10.2307/3284370
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
In this study, we compared the susceptibility of Peromyscus leucopus (white-footed mouse), a common natural intermediate host, and Mus musculus, a commonly used experimental model, to infection with larvae of the raccoon ascarid, Baylisascaris procyonis. Three groups of 10 mice of each species were given 50, 250, or 500 infective B. procyonis eggs by gavage. The mice were observed daily for clinical signs of central nervous system (CNS) disease and at necropsy the distribution of larvae in 10 body regions and organs was determined and compared. Clinical CNS disease developed in 57% of P. leucopus and 93% of M. musculus. The average clinical incubation period was significantly longer in P. leucopus (20.6 days postinfection [PI]) than in M. musculus (10.7 days PI), and clinical disease progressed slower in P. leucopus. Significantly fewer larvae were recovered from P. leucopus than from M. musculus. Most larvae were recovered from the anterior carcass and viscera of P. leucopus and from the carcass, head, and brain of M. musculus. CNS invasion was dose dependent in M. musculus but not in P. leucopus. Few or no grossly visible larval granulomas were present in P. leucopus but were abundant in M. musculus. We concluded that P. leucopus was less susceptible than M. musculus to B. procyonis infection, based on a decreased intensity of infection, longer clinical incubation period or lack of clinical disease, slower progression of disease, different larval distribution. and lower tissue reactivity to larvae.
引用
收藏
页码:1104 / 1111
页数:8
相关论文
共 50 条
  • [1] Foraging among feces:: Food availability affects parasitism of Peromyscus leucopus by Baylisascaris procyonis
    Page, LK
    Swihart, RK
    Kazacos, KR
    [J]. JOURNAL OF MAMMALOGY, 2001, 82 (04) : 993 - 1002
  • [3] MYS RETROTRANSPOSONS IN PEROMYSCUS-LEUCOPUS AND TRANSGENIC MUS-MUSCULUS
    PINE, DS
    BOUREKAS, EC
    POTTER, SS
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (08) : 3359 - 3373
  • [4] Bitter Avoidance in Guinea Pigs (Cavia porcellus) and Mice (Mus musculus and Peromyscus leucopus)
    Field, Kristin L.
    Beauchamp, Gary K.
    Kimball, Bruce A.
    Mennella, Julie A.
    Bachmanov, Alexander A.
    [J]. JOURNAL OF COMPARATIVE PSYCHOLOGY, 2010, 124 (04) : 455 - 459
  • [5] INFLUENCE OF ENVIRONMENTAL COMPLEXITY AND SPACE ON SOCIAL INTERACTIONS OF MICE (MUS, MUSCULUS AND PEROMYSCUS, LEUCOPUS)
    VESTAL, BM
    SCHNELL, GD
    [J]. JOURNAL OF COMPARATIVE PSYCHOLOGY, 1986, 100 (02) : 143 - 154
  • [6] VARIABLE INFECTION DYNAMICS IN FOUR PEROMYSCUS SPECIES FOLLOWING EXPERIMENTAL INOCULATION WITH BAYLISASCARIS PROCYONIS
    Sapp, Sarah G. H.
    Weinstein, Sara B.
    McMahan, Christopher S.
    Yabsley, Michael J.
    [J]. JOURNAL OF PARASITOLOGY, 2016, 102 (05) : 538 - 544
  • [7] Comparing radiation toxicities across species: An examination of radiation effects in Mus musculus and Peromyscus leucopus
    Liu, William
    Haley, Benjamin
    Kwasny, Mary J.
    Li, Jian Jian
    Grdina, David J.
    Paunesku, Tatjana
    Woloschak, Gayle E.
    [J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2013, 89 (06) : 391 - 400
  • [8] Characterizing phenotypic data of Peromyscus leucopus compared to C57BL/6J Mus musculus and diversity outbred (DO) Mus musculus
    Wimer, Lauren A.
    Davis-Castillo, Asia
    Galkina, Sofiya
    Ciotlos, Serban
    Patterson, Cavan
    Prado, Leandro
    Munoz, Maria Castro
    Martin, Nicolas
    Epstein, Sharon
    Schaum, Nicholas
    Melov, Simon
    [J]. GEROSCIENCE, 2024, : 4647 - 4656
  • [9] Neurologic Baylisascaris procyonis infection in a young dog
    Hazlett, Murray
    Cai, Hugh Y.
    Sparling, Stephanie
    You, Qiumei
    [J]. CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE, 2018, 59 (12): : 1325 - 1328
  • [10] AUDITORY SENSITIVITY IN MICE - PEROMYSCUS AND MUS MUSCULUS
    RALLS, K
    [J]. ANIMAL BEHAVIOUR, 1967, 15 (01) : 123 - &