Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes

被引：91
|
作者：
Ackermann, Lutz [1 ]
Vicente, Ruben [1 ]
Hofmann, Nora [1 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 19期
关键词：
CROSS-COUPLING REACTIONS; HETEROCYCLIC CARBENE LIGANDS; SIMPLE INDOLE ALKALOIDS; BOND-FORMING REACTIONS; C-C; ARYL CHLORIDES; RATE ACCELERATION; ACTIVATION; EFFICIENT; KETONES;
D O I：
10.1021/ol901597d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium catalyst derived from air-stable secondary phosphine oxide (1-Ad)(2)P(O)H enabled efficient intramolecular alpha-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.
引用
收藏
页码：4274 / 4276
页数：3
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