Causal links between major depressive disorder and insomnia: A Mendelian randomisation study

被引:23
|
作者
Cai, Lei [1 ]
Bao, Yiran [1 ]
Fu, Xiaoqian [2 ]
Cao, Hongbao [3 ]
Baranova, Ancha [3 ,4 ]
Zhang, Xiangrong [5 ]
Sun, Jing [6 ]
Zhang, Fuquan [5 ,6 ]
机构
[1] Shanghai Jiao Tong Univ, Bio X Inst,Shanghai Key Lab Psychot Disorders 13d, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ,Collaborat Innovat Ctr Genet & Dev, Shanghai 200240, Peoples R China
[2] Soochow Univ, Dept Clin Psychol, Affiliated Guangji Hosp, Suzhou 215131, Jiangsu, Peoples R China
[3] George Mason Univ, Sch Syst Biol, Fairfax, VA 22030 USA
[4] Res Ctr Med Genet, Moscow 115478, Russia
[5] Nanjing Med Univ, Dept Geriatr Psychiat, Affiliated Brain Hosp, Nanjing 210029, Peoples R China
[6] Nanjing Med Univ, Dept Psychiat, Affiliated Brain Hosp, 264 Guangzhou Rd, Nanjing 210029, Peoples R China
基金
中国国家自然科学基金;
关键词
Major depressive disorder; Insomnia; LD score regression; Mendelian randomization; GENOME-WIDE ASSOCIATION; SAMPLE; COMMON; SLEEP; RISK;
D O I
10.1016/j.gene.2020.145271
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Both Major depressive disorder (MDD) and insomnia are two common mental disorders. However, the inherent and comprehensive genetic factors causing the links between MDD and insomnia are unclear yet. Here, based on GWAS results for each disorder, we used linkage disequilibrium (LD) score regression analysis and a multi-single nucleotide polymorphism (SNP) Mendelian randomization (MR) analysis to test the genetic relationships between these two diseases. Genetic correlation analyses indicated that MDD has a significant genetic correlation with insomnia (correlation ratio = 0.40 +/- 0.03, P = 1.12 x 10(-52)). Mendelian randomization analysis indicated that liability to MDD confers a causal effect on insomnia (b(xy) = 0.16 +/- 0.02, P = 1.11 x 10(-18)), while liability to insomnia confers a causal effect on MDD (b(xy) = 0.57 +/- 0.07, P = 1.17 x 10(-14)). We found that the transcription factor 4 (TCF4) gene may contribute to the mutual influences between MDD and insomnia. These results provide insights into the relationships between MDD and insomnia and may have implications for policy, planning, and provision of services.
引用
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页数:5
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