Protein oxidation and cellular homeostasis: Emphasis on metabolism

被引:186
|
作者
Cecarini, Valentina
Gee, Jillian
Fioretti, Evandro
Amici, Manila
Angeletti, Mauro
Eleuteri, Anna Maria
Keller, Jeffrey N. [1 ]
机构
[1] Univ Kentucky, Sanders Brown Ctr Aging 205, Lexington, KY 40536 USA
[2] Univ Camerino, Post Grad Sch Clin Biochem, Dept Mol & Cellular, I-62032 Camerino, Italy
[3] Univ Camerino, Post Grad Sch Clin Biochem, Dept Anim Biol, I-62032 Camerino, Italy
来源
基金
美国国家卫生研究院;
关键词
aging; lysosome; neuron; oxidative stress; proteasome; reactive oxygen specie;
D O I
10.1016/j.bbamcr.2006.08.039
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reactive oxygen species (ROS) are generated as the result of a number of physiological and pathological processes. Once formed ROS can promote multiple forms of oxidative damage, including protein oxidation, and thereby influence the function of a diverse array of cellular processes. This review summarizes the mechanisms by which ROS are generated in a variety of cell types, outlines the mechanisms which control the levels of ROS, and describes specific proteins which are common targets of ROS. Additionally, this review outlines cellular processes which can degrade or repair oxidized proteins, and ultimately describes the potential outcomes of protein oxidation on cellular homeostasis. In particular, this review focuses on the relationship between elevations in protein oxidation and multiple aspects of cellular metabolism. Together, this review describes a potential role for elevated levels of protein oxidation contributing to cellular dysfunction and oxidative stress via impacts on cellular metabolism. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:93 / 104
页数:12
相关论文
共 50 条
  • [1] Confronting Cellular Heterogeneity in Studies of Protein Metabolism and Homeostasis in Aging Research
    Boisen, Louise
    Kristensen, Peter
    PROTEIN METABOLISM AND HOMEOSTASIS IN AGING, 2010, 694 : 234 - 244
  • [2] Cellular iron homeostasis and metabolism in plant
    Vigani, Gianpiero
    Zocchi, Graziano
    Bashir, Khurram
    Philippar, Katrin
    Briat, Jean Francois
    FRONTIERS IN PLANT SCIENCE, 2013, 4
  • [3] Cellular metabolism and homeostasis in pluripotency regulation
    Liu, Kun
    Cao, Jiani
    Shi, Xingxing
    Wang, Liang
    Zhao, Tongbiao
    PROTEIN & CELL, 2020, 11 (09) : 630 - 640
  • [4] Cellular metabolism and homeostasis in pluripotency regulation
    Kun Liu
    Jiani Cao
    Xingxing Shi
    Liang Wang
    Tongbiao Zhao
    Protein & Cell, 2020, 11 (09) : 630 - 640
  • [5] Streptococcus pneumoniaemetal homeostasis alters cellular metabolism
    Burcham, Lindsey R.
    Hill, Rebecca A.
    Caulkins, Rachel C.
    Emerson, Joseph P.
    Nanduri, Bindu
    Rosch, Jason W.
    Fitzkee, Nicholas C.
    Thornton, Justin A.
    METALLOMICS, 2020, 12 (09) : 1416 - 1427
  • [6] Autophagy: A critical regulator of cellular metabolism and homeostasis
    Ryter, Stefan W.
    Cloonan, Suzanne M.
    Choi, Augustine M. K.
    MOLECULES AND CELLS, 2013, 36 (01) : 7 - 16
  • [7] Cellular maintenance of nuclear protein homeostasis
    Pamela S. Gallagher
    Michelle L. Oeser
    Ayelet-chen Abraham
    Daniel Kaganovich
    Richard G. Gardner
    Cellular and Molecular Life Sciences, 2014, 71 : 1865 - 1879
  • [8] Cellular maintenance of nuclear protein homeostasis
    Gallagher, Pamela S.
    Oeser, Michelle L.
    Abraham, Ayelet-chen
    Kaganovich, Daniel
    Gardner, Richard G.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (10) : 1865 - 1879
  • [9] A road map of cellular protein homeostasis
    Ang, Xiaolu L.
    Harper, J. Wade
    NATURE CHEMICAL BIOLOGY, 2009, 5 (01) : 9 - 11
  • [10] Mitochondrial control of cellular protein homeostasis
    Mohanraj, Karthik
    Nowicka, Urszula
    Chacinska, Agnieszka
    BIOCHEMICAL JOURNAL, 2020, 477 (16) : 3033 - 3054