Efficacy of a new small-molecule inhibitor of histone deacetylase 6 (HDAC6) in preclinical models of B-cell lymphoma and acute myeloid leukemia

被引:0
|
作者
Villanueva, Lorea [1 ]
Perez-Salvia, Montserrat [1 ]
Aldaba, Eneko [2 ]
Vara, Yosu [2 ]
Fabre, Myriam [3 ]
Ferrer, Cristina [3 ]
Masdeu, Carme [4 ]
Zubia, Aizpea [4 ]
San Sebastian, Eider [4 ]
Otaegui, Dorleta [5 ]
Llinas-Arias, Pere [1 ]
Rossello-Tortella, Margalida [1 ]
Berdasco, Maria [1 ]
Setien, Fernando [1 ]
Moutinho, Catia [1 ]
Villanueva, Alberto [6 ]
Gonzalez-Barca, Eva [6 ]
Muncunill, Josep [7 ]
Tomas Navarro, Jose [7 ]
Angel Piris, Miguel [8 ]
Cossio, Fernando [4 ]
Esteller, Manel [1 ]
机构
[1] Canc Epigenet & Biol Program PEBC, Barcelona, Spain
[2] Quimatryx, San Sebastian, Spain
[3] Oncomatryx, Derio, Spain
[4] Univ Basque Country, San Sebastian, Spain
[5] CIC BiomaGUNE, San Sebastian, Spain
[6] Catalan Inst Oncol ICO, Barcelona, Spain
[7] Josep Carreras Res Inst IJC, Badalona, Spain
[8] Fdn Jimenez Diaz, Madrid, Spain
关键词
D O I
10.1158/1538-7445.SABCS18-4725
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4725
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia
    Perez-Salvia, Montserrat
    Eneko, Aldaba
    Yosu, Vara
    Myriam, Fabre
    Cristina, Ferrer
    Carme, Masdeu
    Aizpea, Zubia
    Sebastian Eider, San
    Dorleta, Otaegui
    Pere, Llinas-Arias
    Margalida, Rossello-Tortella
    Maria, Berdasco
    Fernando, Setien
    Catia, Moutinho
    Alberto, Villanueva
    Gonzalez-Barca, Eva
    Muncunill, Josep
    Tomas Navarro, Jose
    Angel Piris, Miguel
    Fernando, Cossio
    Esteller, Manel
    [J]. BLOOD, 2018, 132
  • [2] Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
    Haggarty, SJ
    Koeller, KM
    Wong, JC
    Grozinger, CM
    Schreiber, SL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) : 4389 - 4394
  • [3] In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
    Perez-Salvia, Montserrat
    Aldaba, Eneko
    Vara, Yosu
    Fabre, Myriam
    Ferrer, Cristina
    Masdeu, Carme
    Zubia, Aizpea
    San Sebastian, Eider
    Otaegui, Dorleta
    Llinas-Arias, Pere
    Rossello-Tortella, Margalida
    Berdasco, Maria
    Moutinho, Catia
    Setien, Fernando
    Villanueva, Alberto
    Gonzalez-Barca, Eva
    Muncunill, Josep
    Navarro, Jose-Tomas
    Piris, Miguel A.
    Cossio, Fernando P.
    Esteller, Manel
    [J]. HAEMATOLOGICA, 2018, 103 (11) : E537 - E540
  • [4] Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
    Auzmendi-Iriarte, Jaione
    Saenz-Antonanzas, Ander
    Mikelez-Alonso, Idoia
    Carrasco-Garcia, Estefania
    Tellaetxe-Abete, Maitena
    Lawrie, Charles H.
    Sampron, Nicolas
    Cortajarena, Aitziber L.
    Matheu, Ander
    [J]. CELL DEATH & DISEASE, 2020, 11 (06)
  • [5] Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
    Jaione Auzmendi-Iriarte
    Ander Saenz-Antoñanzas
    Idoia Mikelez-Alonso
    Estefania Carrasco-Garcia
    Maitena Tellaetxe-Abete
    Charles H. Lawrie
    Nicolás Sampron
    Aitziber L. Cortajarena
    Ander Matheu
    [J]. Cell Death & Disease, 11
  • [6] Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
    Yang, Ka
    Song, Yanling
    Xie, Haibo
    Wu, Hao
    Wu, Yi-Ting
    Leisten, Eric D.
    Tang, Weiping
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (14) : 2493 - 2497
  • [7] Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors
    Smil, David V.
    Manku, Sukhdev
    Chantigny, Yves A.
    Leit, Silvana
    Wahhab, Amal
    Yan, Theresa P.
    Fournel, Marielle
    Maroun, Christiane
    Li, Zuomei
    Lemieux, Anne-Marie
    Nicolescu, Alina
    Rahil, Jubrail
    Lefebvre, Sylvain
    Panetta, Anthony
    Besterman, Jeffrey M.
    Deziel, Robert
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) : 688 - 692
  • [8] Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology
    Mondal, Prasenjit
    Bai, Ping
    Gomm, Ashley
    Bakiasi, Grisilda
    Lin, Chih-Chung Jerry
    Wang, Yanli
    Choi, Se Hoon
    Tanzi, Rudolph E.
    Wang, Changning
    Zhang, Can
    [J]. ADVANCED SCIENCE, 2024, 11 (01)
  • [9] Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma
    Hideshima, Teru
    Qi, Jun
    Paranal, Ronald M.
    Tang, Weiping
    Greenberg, Edward
    West, Nathan
    Colling, Meaghan E.
    Estiu, Guillermina
    Mazitschek, Ralph
    Perry, Jennifer A.
    Ohguchi, Hiroto
    Cottini, Francesca
    Mimura, Naoya
    Goerguen, Guellue
    Tai, Yu-Tzu
    Richardson, Paul G.
    Carrasco, Ruben D.
    Wiest, Olaf
    Schreiber, Stuart L.
    Anderson, Kenneth C.
    Bradner, James E.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (46) : 13162 - 13167
  • [10] Selective Inhibition of Histone Deacetylase 6 (HDAC6) and HDAC3 As a Novel Therapeutic Strategy in Mantle Cell Lymphoma (MCL)
    Cheng, Fengdong
    Xia, Bing
    Sahakian, Eva
    Lwin, Tint
    Wang, Hongwei
    Xing, Limin
    Shah, Bijal D.
    PerezVillarroel, Patricio
    LienlafMoreno, Maritza
    Zhang, Yizhuo
    Quayle, Steven N.
    Jones, Simon S.
    Pinilla-Ibarz, Javier
    Villagra, Alejandro
    Sotomayor, Eduardo M.
    Tao, Jianguo
    [J]. BLOOD, 2014, 124 (21)