Distinct functions of COX-1 and COX-2

被引：344
|
作者：
Morita, I [1 ]
机构：
[1] Tokyo Med & Dent Univ, Grad Sch, Dept Cellular Physiol Chem, Bunkyo Ku, Tokyo 1138549, Japan
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2002年 / 68-9卷
关键词：
COX-1; COX-2; knockout mouse;
D O I：
10.1016/S0090-6980(02)00029-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-2 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was involved in various pathologies. However, studies with COX-2 knockout mouse suggest that COX-2 also plays important roles in development and homeostasis. This chapter focuses on the distinct functions of COX-1 and COX-2. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：165 / 175
页数：11
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